Title Page -- Copyright Page -- Contents -- Dedication and Foreword -- Preface -- Contributors List -- Section 1 General Topics -- Chapter 1 Introduction: Use, Definitions, History, Concepts, Classification, and Considerations for Anesthesia and Analgesia -- Introduction -- Use of anesthesia, sedation, and analgesia -- Definitions -- Brief history of animal anesthesia -- History of North American organizations -- Anesthesiologist defined -- Early conceptual stages of anesthesia -- Classification of anesthesia -- Environmental considerations -- References -- Chapter 2 Anesthetic Risk and Informed Consent -- Anesthetic risk assessment -- Morbidity and mortality -- Informed consent -- References -- Chapter 3 Anesthesia Equipment -- Introduction -- Safety and design -- Introduction to airway management and support equipment -- Endotracheal tubes, lung isolation devices, supraglottic airway devices, laryngoscopes, intubation aids and techniques -- Techniques of oxygen administration -- Introduction anesthetic machine and breathing circuits -- Medical gas supply -- The modern anesthetic machine -- Breathing systems -- Waste gas scavenge system -- Anesthesia ventilators -- Respiratory assist devices -- Acknowledgement -- References -- Chapter 4 Monitoring Anesthetized Patients -- Introduction -- Monitoring anesthetic depth -- Cardiovascular system -- Pulmonary system -- Temperature -- References -- Chapter 5 Anesthetic Emergencies and Resuscitation -- Introduction -- Cardiovascular -- Respiratory system -- Drug factors -- Equipment -- Regional anesthesia -- Other factors -- Critical event debriefing -- References -- Chapter 6 Euthanasia and Humane Killing -- Introduction -- Terminology -- Pain and consciousness -- Mechanisms of action -- Evaluating animal distress -- Choice of killing method relative to onset of unconsciousness.

Fetal sentience and euthanasia -- Low atmospheric pressure stunning -- Foam depopulation -- Agent purity and euthanasia -- Euthanasia in the clinical setting -- References -- Section 2 Pharmacology -- Chapter 7 General Pharmacology of Anesthetic and Analgesic Drugs -- Introduction -- Classical receptor theory -- Receptor state theory -- Receptor structure -- Clinical evaluation of drug effects -- Pharmacokinetics and pharmacodynamics -- Experiments in pharmacokinetics -- Constant rate therapy -- Drug interactions -- Adverse drug reactions -- Drug metabolism -- References -- Chapter 8 Anticholinergics -- Introduction -- History -- General pharmacology -- Specific anticholinergic drugs -- References -- Chapter 9 Adrenergic Agents -- Introduction -- Catecholamines and other adrenergic agonists -- Adrenergic receptor antagonists -- References -- Chapter 10 Sedatives and Tranquilizers -- Introduction -- Phenothiazines -- Benzodiazepines -- α2-Adrenergic receptor agonists -- α2-Adrenergic receptor antagonists -- References -- Chapter 11 Opioids -- Introduction -- Opioid receptors -- Pharmacokinetics -- Clinical effects of opioids -- Analgesia -- Opioid agonists -- Partial opioid agonists and agonist/antagonists -- Tramadol -- Opioid antagonists -- References -- Chapter 12 Non-Steroidal Anti-Inflammatory Drugs -- Introduction -- Mechanism of action -- Pharmacokinetic properties -- Pharmacokinetic-pharmacodynamic (PK-PD) properties -- Adverse effects of NSAIDs -- Kidney injury related to NSAID administration -- Blood coagulation effects: Platelet inhibition and thrombotic abnormalities -- Drug selection -- Summary -- References -- Chapter 13 Anesthetic and Analgesic Adjunctive Drugs -- Introduction -- Non-analgesic adjuncts -- Analgesic adjuncts -- References -- Chapter 14 Muscle Relaxants and Neuromuscular Blockade -- History of muscle relaxants.

Physiology of the neuromuscular junction -- Pharmacology -- Individual neuromuscular blocking drugs -- Non-neuromuscular effects of NMBAs -- Muscle relaxants in anesthetized animals -- Factors affecting neuromuscular blockade -- Monitoring neuromuscular blockade -- Reversal of neuromuscular blockade -- Centrally acting muscle relaxants -- References -- Chapter 15 Injectable Anesthetics -- Introduction -- Barbiturates -- Propofol -- Dissociative anesthetics -- Etomidate -- Alfaxalone -- Other drugs -- References -- Chapter 16 Inhalation Anesthetics -- Introduction -- Physicochemical characteristics -- Pharmacokinetics: uptake and elimination of inhalation anesthetics -- Anesthetic dose: the minimum alveolar concentration (MAC) -- Pharmacodynamics: actions and toxicity of the volatile inhalation anesthetics on body systems -- The gaseous anesthetic: Nitrous oxide (N2O) -- Waste inhalation anesthetics -- References -- Chapter 17 Local Anesthetics -- Introduction -- Pharmacology -- Clinical pharmacology -- Specific drugs and clinical uses -- Adverse effects -- References -- Section 3 Body Fluids and Thermoregulation -- Chapter 18 Acid-Base Physiology -- Introduction -- Acids, bases, pH, pK, and the Henderson-Hasselbalch equation -- Body buffering systems -- Temperature effects on acid-base balance -- Acid-base terminology -- Anion gap -- Strong ion difference -- Clinical acid-base disturbances -- Evaluations of acid-base balance -- References -- Chapter 19 Perioperative Thermoregulation and Heat Balance -- Introduction -- Thermodynamics -- Thermoregulation -- Core-to-periphery gradient -- Mechanisms of heat transfer -- Active patient warming -- Hyperthermia -- Clinical significance of hypothermia -- Perianesthetic management of hypothermia -- References -- Chapter 20 Treatment of Coagulation and Platelet Disorders -- Introduction.

The cell-based model of hemostasis -- Coagulation and platelet function testing -- Anticoagulant therapy -- Fibrinolytic drugs -- Procoagulant therapies -- Drugs that support coagulation -- References -- Chapter 21 Clinical Pharmacology and Administration of Fluid, Electrolyte, and Blood Component Solutions -- Physiology of body fluids -- Different types of fluids used in clinical practice -- Perioperative fluid therapy -- Electrolytes -- Transfusion therapy -- Adverse effects of transfusion -- Alternatives to allogenic blood transfusions -- Strategies to minimize perioperative blood loss -- References -- Section 4 Cardiovascular System -- Chapter 22 Cardiovascular Physiology -- Introduction -- Circulatory system -- Blood -- Lymphatic System -- Special circulations -- Hemorrheology -- Hemodynamics -- Determinants of cardiac performance and cardiac output -- Neurohumoral and local control mechanisms -- Oxygen delivery and uptake -- References -- Chapter 23 Cardiac Output Measurement -- Introduction -- Basic principles of cardiac output monitoring -- History of cardiac output measurement -- Techniques of determination of cardiac output -- References -- Chapter 24 Anesthesia for Cardiopulmonary Bypass -- Introduction -- The circuitry and patient cannulation -- Systemic responses - pathobiology -- Drugs and interventions used during cardiopulmonary bypass -- Preanesthetic preparation -- The sequence of events and terminology -- Conclusion -- References -- Chapter 25 Cardiac Pacemakers and Anesthesia -- Introduction -- Artificial pacemakers -- Pacemaker modalities -- Anesthetic management -- Pacemaker patients undergoing non-cardiac procedures -- Conclusion -- References -- Chapter 26 Pathophysiology and Anesthetic Management of Patients with Cardiovascular Disease -- Introduction -- Preanesthetic evaluation -- Anesthesia for specific conditions.

Diseases associated with arrhythmias -- Hypotension -- Shock -- References -- Section 5 Respiratory System -- Chapter 27 Physiology, Pathophysiology, and Anesthetic Management of Patients with Respiratory Disease -- Introduction -- Respiratory function in conscious normal animals -- Respiratory function in the anesthetized animal -- Changes in ventilation-perfusion relationships during anesthesia -- Oxygen therapy and mechanical ventilation -- Clinical implications of altered respiration during anesthesia -- Anesthesia for animals with respiratory disease or dysfunction -- References -- Section 6 Nervous System -- Chapter 28 Physiology, Pathophysiology, and Anesthetic Management of Patients with Neurologic Disease -- Introduction -- Anatomy of the nervous system -- Physiology/pathophysiology of the central nervous system -- General anesthesia -- Neurologic monitoring and testing -- Management of selected nervous system disease states -- Advanced imaging modalities (myelography, magnetic resonance imaging) -- References -- Chapter 29 Nociception and Pain -- Introduction -- Pain and nociception -- Pain classification -- Pain physiology -- Pain pathophysiology - clinical pain -- Central changes -- Chronic pain -- Models of nociception and analgesic testing -- Nociceptive and pain assays -- Clinical pain assessment in veterinary medicine -- Pharmacologic treatment of pain -- α2-Adrenergic receptor agonists -- Local anesthetics -- N-Methyl-d-aspartate receptor antagonists -- Non-steroidal anti-inflammatory drugs (NSAIDs) -- Opioids -- Adjunctive analgesics -- Non-pharmacologic modifiers of pain -- Tissue deformation -- Neuromodulatory activities -- Peripheral neuromodulation (mechano-transduction) -- Spinal neuromodulation -- Central neuromodulation -- Kinematic training -- Stimulation of metabolism and blood flow.

Muscle spasm, myofascial trigger points, and pain.