Novel ProcessWindows -- Contents -- Motivation - Who should read the book!? -- Acknowledgments -- Abbreviations -- Nomenclature -- Chapter 1 From Green Chemistry to Green Engineering - Fostered by Novel Process Windows Explored in Micro-Process Engineering/Flow Chemistry -- 1.1 Prelude - Potential for Green Chemistry and Engineering -- 1.2 Green Chemistry -- 1.2.1 12 Principles in Green Chemistry -- 1.3 Green Engineering -- 1.3.1 10 Key Research Areas in Green Engineering -- 1.3.2 12 Principles in Chemical Product Design -- 1.4 Micro- and Milli-Process Technologies -- 1.4.1 Microreactors -- 1.4.2 Microstructured Reactors -- 1.5 Flow Chemistry -- 1.5.1 10 Key Research Areas in Flow Chemistry -- 1.6 Two Missing Links - Cross-Related -- References -- Chapter 2 Novel Process Windows -- 2.1 Transport Intensification - The Potential of Reaction Engineering -- 2.2 Chemical Reactivity in Match or Mismatch to Intensified Engineering -- 2.3 Chemical Intensification through Harsh Conditions - Novel Process Windows -- 2.4 Flash Chemistry -- 2.5 Process-Design Intensification -- References -- Chapter 3 Chemical Intensification - Fundamentals -- 3.1 Length Scale -- 3.2 Time Scale -- 3.3 Length and Time Scale of Chemical Reactions -- 3.3.1 Solution of Kinetic Equations -- 3.3.2 Reaction Time and Reaction Classification -- 3.3.3 Example for Reaction Time and Residence Time -- 3.4 Temperature Intensification -- 3.4.1 Harsh Process Conditions -- 3.4.2 New Temperature Windows -- 3.4.3 Reaction Rate - Arrhenius Equation -- 3.5 Pressure Intensification -- 3.5.1 Reaction Rate - Activation Volumes -- 3.5.2 Equilibrium -- 3.5.3 Electron Kinetic Energy -- 3.5.4 Material Properties -- 3.5.5 Mixture Properties -- 3.5.6 Illustration of Pressure Effect on Selected Chemical Reactions -- References.

Chapter 4 Making Use of the "Forbidden" - Ex-Regime/High Safety Processing -- 4.1 Hazardous Reactants and Intermediates -- 4.1.1 Tetrazole Formation -- 4.1.2 Strecker Synthesis -- 4.1.3 Phosgene Chemistry -- 4.1.4 Diazomethane Synthesis -- 4.1.5 Ozonolysis -- 4.1.6 Organic Peroxide Formation -- 4.2 Ex-Regime and Thermal Runaway Processing -- 4.2.1 Oxidation -- 4.2.2 Hydrogen Peroxide Synthesis -- 4.2.3 Direct Fluorination -- 4.2.4 Ionic Liquid Synthesis -- 4.2.5 Moffatt-Swern Oxidation -- 4.2.6 Reaction Between Cyclohexanecarboxylic Acid and Oleum -- 4.2.7 Nitration of Toluene -- 4.2.8 Aromatic Amidoxime Formation -- 4.2.9 Decarboxylative Trichloromethylation of Aromatic Aldehydes -- 4.2.10 Dihydroxylation Reactions with Nanobrush-Immobilized OsO4 -- References -- Chapter 5 Exploring New Paths - New Chemical Transformations -- 5.1 Direct Syntheses via One Step -- 5.1.1 Fluorination with Elemental Fluorine -- 5.1.2 Hydrogen Peroxide Synthesis out of the Elements -- 5.1.3 Direct Aryllithiums Route -- 5.1.4 C-O Bond Formation by a Direct α-C-H Bond Activation -- 5.1.5 Direct Adipic Acid Route from Cyclohexene -- 5.1.6 New Biocatalytic Pathways without Protecting Groups - Inter-Glycosidic Condensation -- 5.2 Direct Syntheses via Multicomponent Reactions -- 5.2.1 "Odor-Sealed" Isocyanide Formation -- 5.3 Multistep One-Flow Syntheses -- 5.4 Multistep Syntheses in One Microreactor/Chip -- 5.4.1 Multistep Synthesis of [18F]-Radiolabeled Molecular Imaging Probe -- 5.4.2 Combining Asymmetric Organocatalysis and Analysis on a Single Microchip -- 5.4.3 Two-Step Strecker Reaction -- 5.5 Multistep Syntheses in Coupled Microreactors/Chips -- 5.5.1 Chlorohydrination of Allyl Chloride -- 5.5.2 Lithiation/Borylation/Suzuki-Miyaura Cross-Coupling.

5.5.3 Suzuki-Miyaura Cross-Coupling-Phenols-Aryl Triflates-Biaryls -- 5.5.4 Ring-Closing Metathesis and Heck Reaction -- 5.5.5 Imidazo[1,2-a]pyridine-2-carboxylic Acids in Two Steps -- 5.5.6 Suzuki-Miyaura Cross-Coupling/Hydrogenation -- 5.5.7 Sodium Nitrotetrazolate - Diazonium Ion Formation/Sandmeyer Reaction -- 5.5.8 Murahashi Coupling/Br-Li Exchange -- 5.5.9 5′-Deoxyribonucleoside Glycosylation -- 5.5.10 Two-Carbon Homologation of Esters to α,β-Unsaturated Esters -- 5.5.11 Low-Pressure Carbonylations with Acids as CO Precursors -- 5.5.12 Coupled Microreactor-Purification-Analytics for δ-Opioid Receptor Agonist -- 5.5.13 Synthesis of TAC-101 Analogs -- 5.5.14 Multistep Enzymatic Synthesis to 2-Amino-1,3,4-Butanetriol -- 5.5.15 Multistep Enzymatic Synthesis to δ-d-Gluconolactone -- 5.5.16 Diarylethene Synthesis in Two Steps -- References -- Chapter 6 Activate - High-T Processing -- 6.1 Tailored High-T Microreactor Design and Fabrication -- 6.1.1 Glass Capillary Coil in Ceramic Housing -- 6.1.2 Modularly Packaged Silicon Microreactor -- 6.1.3 Modular Thermal Platform for High-Temperature Flow Reactions -- 6.2 Cryogenic to Ambient - Allowing Fast Reactions to be Fast -- 6.2.1 Synthesis of Triflates for the Heck Alkenylation -- 6.2.2 Enantioselective 1,4-Addition of Enones -- 6.2.3 Swern-Moffatt Oxidation of Benzyl Alcohol -- 6.2.4 Tf2NH-Catalyzed [2+2] Cycloaddition -- 6.3 From Reflux to Superheated - Speeding-Up Reactions -- 6.3.1 Kolbe-Schmitt Reaction -- 6.3.2 C-F Bond Formation -- 6.3.3 NMP Radical Polymerization of Styrene -- 6.3.4 Noncatalytic Claisen Rearrangement -- 6.3.5 Nucleophilic Substitution of Difluoro-benzenes -- 6.3.6 Aminolysis of Epoxides -- 6.3.7 Synthesis of 2,4,5-Trisubstituted Imidazoles.

6.3.8 2-Methylbenzimidazole Formation, 3,5-Dimethyl-1-Phenylpyrazole Formation, and Diels-Alder Cycloaddition - Benchmarking High-p,t Flow to Microwave -- 6.3.9 Fischer Indole Synthesis of Tetrahydrocarbazole -- 6.3.10 Thermal Hydrolysis of Triglycerides -- 6.3.11 Chlorodehydroxylation to n-Alkyl Chlorides -- 6.3.12 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles -- 6.3.13 Cobalt-Catalyzed Borohydride Reduction of Tetralone -- 6.3.14 Dimethylcarbonate Methylation -- 6.3.15 Selective Aerobic Oxidation of Benzyl Alcohol Using Iron Oxide Nano-/TEMPO Catalyst -- 6.3.16 Rufinamide Synthesis -- 6.3.17 Several High-T, High-p Processes -- 6.3.18 Click Chemistry -- 6.3.19 4-(Pyrazol-1-yl) Carboxanilide Multistep Synthesis -- 6.3.20 4-Hydroxy-2-cyclopentenone Synthesis -- 6.3.21 Hydrothermal Treatment of Glucose -- 6.3.22 Tetrahydroisoquinoline Synthesis -- 6.4 Solvent-Scope Widening by Virtue of Pressurizing Existing High-T Reactions -- 6.4.1 Nucleophilic Aromatic Substitution of 2-Halopyridines -- 6.4.2 Intramolecular Thermal Cyclization and Benzannulation -- 6.4.3 Catalyst-Free Transesterification and Esterification of Aliphatic and Aromatic Acids -- 6.4.4 Aminolysis of Epoxides -- 6.5 New Temperature Field for Product and Material Control -- 6.5.1 Palladium-Catalyzed Aminocarbonylation -- 6.5.2 Aminolysis of Epoxides -- 6.5.3 Flash Flow Pyrolysis -- 6.5.4 Indium Phosphide Nanocrystal -- 6.5.5 Quantum Dot Synthesis -- 6.5.6 High-T Flow Cycloaddition to Fullerene Derivatives -- 6.6 Energy Activation Other than Temperature - Photo, Electrochemical, Plasma -- 6.6.1 Photo-Oxygenation of Dimethylsulfide -- 6.6.2 Microwave Flow Reactor for Stable High-p,T Operation -- References -- Chapter 7 Press - High-p Processing -- 7.1 Tailored High-p Microreactor Design and Fabrication.

7.1.1 Solder-Based Silicon Microsystem -- 7.1.2 In-Plane Fiber-Based Interfaced Microreactor -- 7.2 High Pressure to Intensify Interfacial Transport in Gas-Liquid Reactions -- 7.2.1 Hydrogenation of Cyclohexane -- 7.2.2 Carbamic Acid Formation -- 7.2.3 Intramolecular Aldol Condensation to 1-Methyl-1-cyclopenten-3-one -- 7.2.4 Catalytic Hydrogenation of Acetone -- 7.2.5 Propylene Oxide Synthesis -- 7.2.6 Asymmetric Amino-2-indanol Hydrogenation -- 7.2.7 Hydrogen Gas Liquefication in Guaiacol Conversion (hydroprocessing) -- 7.3 Pressure as Direct Means - Activation Volume Effects and More -- 7.3.1 Claisen Rearrangement -- 7.3.2 Nucleophilic Aromatic Substitution of Three p-Halonitrobenzenes -- 7.3.3 Diels-Alder Reaction with Furylmethanols and Cyclopentadiene -- 7.3.4 Aza Diels-Alder Reaction -- 7.3.5 Esterification of Phthalic Anhydride -- 7.4 Pressure for Advanced Fluidic Studies - to be Used for Shaping Materials and More -- 7.4.1 scCO2 Droplets or Jets in Liquid Water -- References -- Chapter 8 Collide and Slide - High-c and Tailored-Solvent Processing -- 8.1 Batch Process-Based Inspirations for High-c Flow Processes -- 8.1.1 Polypropylene and Polycarbonate Polymerizations -- 8.1.2 Enantioselective Thermal and Photochemical Solid-State Reaction -- 8.2 Solvent-Free or Solvent-Less Operation - "Highest-c" -- 8.2.1 Bromination of 3-Bromo-imidazo[1,2-a]Pyridine -- 8.2.2 Thiophene Bromination -- 8.2.3 Claisen Rearrangement of Substituted Phenyl Phenols -- 8.2.4 Michael Addition -- 8.2.5 Peroxidation of Methyl Ethyl Ketone -- 8.2.6 Beckmann Rearrangement (High-c) -- 8.2.7 [2+2] Photocycloaddition of a Chiral Cyclohexenone (High-c) -- 8.2.8 Bromination of Toluene (Solvent-Free) -- 8.2.9 Sulfonation of Nitrobenzene (Solvent-Free) -- 8.2.10 Synthesis of Nitro Herbicides (High-c, Solvent-Free).

8.2.11 Suzuki-Miyaura Reaction over Sol-Gel Entrapped Catalyst SiliaCat DPP-Pd.