Atherothrombosis and Coronary Artery Disease -- Contents -- Contributors -- PREFACE -- Introduction -- A Historical Perspective on Atherosclerosis and Coronary Artery Disease -- Prevalence, Incidence, and Mortality of Coronary Heart Disease -- PART I Major Risk Factors and Primary Prevention -- Overview -- Lipid Abnormalities -- Nutrition, Lipid Disorders, and the Metabolic Syndrome -- Genetic Dyslipoproteinemias -- Structure and Function of the Plasma Lipoproteins and Their Receptors -- Plasma High-Density Lipoproteins and Atherogenesis -- Lipoprotein Oxidation, Arterial Inflammation, and Atherogenesis -- Lipoprotein(a) -- Clinical Classifications of Lipid Abnormalities -- Management and Adult Treatment Panel III Guidelines -- Impact of Management on Stabilization of Plaque and Reduction of Cardiovascular Events -- Hypertension, Cigarette Smoking, Diabetes, Obesity, and Others -- Hypertension Genetics and Mechanisms -- Role of Angiotensin in the Pathobiology of Cardiovascular Disease -- Clinical Classifications of Hypertensive Diseases -- Management of Hypertension -- Hypertensive Heart Disease -- Smoking and Atherothrombosis -- Diabetes, Obesity, and the Metabolic Syndrome -- Estrogen and Atherothrombosis -- Vitamins in Coronary Artery Disease -- II Pathogenesis of Atherothrombosis -- General Principles -- Developmental Biology of the Vasculature -- Molecular Basis of Vasculogenesis, Angiogenesis, and Arteriogenesis -- Embryogenesis of the Vascular System -- Mouse Models of Lipoprotein Disorders and Atherosclerosis -- Genetics of Atherothrombotic Disease -- The Normal Artery -- Vascular Endothelium -- Role of Alterations in the Differentiated State of the Smooth Muscle Cell in Atherothrombogenesis -- The Vascular Extracellular Matrix -- The Lesions of Atherothrombosis -- Histologic Classification of Human Atherosclerotic Lesions.

Pathogenesis of Atherothrombosis -- Atherothrombosis in Youth -- Coronary Thrombosis - Local and Systemic Factors -- Special Pathogenetic Factors -- Leukocytes, Adhesion Molecules, and Chemokines in Atherothrombosis -- The Role of Macrophages -- The Role of Lymphocyte -- Viral Activation and Causation of Atherothrombosis and Thrombosis -- Cytokines and Growth Regulatory Molecules -- The Role of Rheology in Atherothrombotic Coronary Artery Disease -- Interaction of Platelet Activation and Coagulation -- Interaction of Platelet Activation and Thrombosis -- Coronary Spasm and Atherothrombosis -- Transplant Arteriosclerosis -- Vascular Grafts and Their Sequelae -- Genomics and Gene Transfer -- Nonatherothrombotic Coronary Artery Disease -- The Microcirculation in Atherothrombotic Coronary Artery Disease -- III Markers and Evolving Imaging of Atherothrombotic Disease -- Inflammatory Markers -- Evolving Invasive and Noninvasive Imaging Techniques in Atherothrombotic Disease -- Endovascular Assessment of the High-Risk Plaque -- Computed Tomography of the Heart -- Magnetic Resonance Imaging of the Heart in Coronary Artery Disease -- Noninvasive Imaging of the Vascular System -- IV Acute Coronary Syndromes -- Pathophysiology and Pathogenesis -- Definitions of Acute Coronary Syndromes -- Pathology of Myocardial Ischemia, Infarction, Reperfusion, and Sudden Death -- The Pathophysiology and Biochemistry of Myocardial Ischemia, Necrosis, and Reperfusion -- Triggering of Onset of Myocardial Infarction and Sudden Cardiac Death -- Clinical Presentation -- Clinical Presentation and Diagnostic Evaluation of Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction -- Clinical Presentation and Diagnostic Evaluation of ST-Segment Elevation Myocardial Infarction -- The Role of Echocardiography -- The Role of Radionuclide Imaging.

The Role of Hemodynamic Assessment -- The Role of Cardiac Magnetic Resonance in the Clinical Presentation of Acute Coronary Syndromes -- The Role of Positron Emission Tomography -- Management -- Medical Management of Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction -- Medical Management of ST-Segment Elevation Acute Myocardial Infarction -- Thrombolytic Therapy -- The Role of Percutaneous Coronary Intervention -- Antithrombotics During the Acute Phase -- Ischemic Ventricular Arrhythmias -- Atherothrombosis, The Conduction System, and Cardiac Pacing -- Sudden Cardiac Death -- Cardiogenic Shock -- Mechanical Complication of Acute Myocardial Infarction -- Right Ventricular Myocardial Infarction -- Acute Coronary Syndromes - The Role of Bypass Surgery in the Management of Unstable Angina and Acute Myocardial Infarction -- Management of the Patient with Unstable Angina, Non-ST-Segment Elevation, and STSegment Elevation Myocardial Infarction after Initial Stabilization and after Discharge -- Value of Myocardial Perfusion Scintigraphy in Risk Stratification and Clinical Decision-making -- Role of Signal Averaging -- Role of Electrophysiologic Testing Before Hospital Discharge -- Role of Renin-Angiotensin-Aldosterone System in Cardiovascular Disease - Pathophysiologic Insights and Therapeutic Implications -- Role of β-Adrenergic Blockade -- Antithrombotic Therapy after Discharge -- Cardiac Rehabilitation and Risk Factor Modification -- Other Unstable Conditions -- Variant Angina Pectoris -- Silent Ischemia in Unstable Angina -- V Chronic Stable Angina -- Pathophysiology of Chronic Stable Angina -- Clinical Presentation and Diagnostic Techniques -- Medical Management -- Interventional Approach -- Role of Coronary Angiography -- Interventional Applications of Coronary Intravascular Ultrasound, Doppler Flow, and Fractional Flow Reserve.

Percutaneous Coronary Revascularization for Chronic Coronary Artery Disease -- Clinical Evaluation of Restenosis -- Use of New Angioplasty Devices for the Treatment of Stable Angina -- Role of Bypass Surgery -- Other Stable Conditions -- Silent Ischemia -- Chest Pain with Normal Coronary Angiograms -- VI Noncoronary Atherothrombosis -- Epidemiologic Relation of Cardiovascular Disease among Different Vascular Territories -- Diagnosis and Treatment of Atherothrombotic Diseases of the Aorta -- Cerebrovascular Disease and Neurologic Manifestations of Heart Disease -- Diagnosis and Management of Diseases of the Peripheral Arteries and Veins -- Surgical Treatment of Peripheral Vascular Disease -- Nonsurgical Management of Carotid Disease -- Minimally Invasive Treatment of Peripheral Vascular Disease -- Behavioral and Alternative Medicine in the Treatment of Atherothrombosis -- Subject Index.