HONEY -- HONEY -- Contents -- Preface -- Selected Topics on Honey Volatile Organic Compounds Research -- Abstract -- Introduction -- Origin and Chemical Classification of Honey Volatile Organic Compounds -- Modern Methods of Honey Volatiles Extraction -- Organic Volatiles as Potential Chemical Markers of the Honey Botanical Origin -- Honey Organic Volatiles as Bioactive Compounds -- Conclusion -- References -- Honey Melanoidins: Emerging Novel Understanding on the Mechanism of Antioxidant and Antibacterial Action of Honey -- Abstract -- Introduction -- 1. Overview of Compounds Involved in Antioxidant Activity of Honey -- 1.1. Contribution of Polyphenols to Antioxidant Activity of Honey -- 1.2. Common Structural Determinants for Antioxidant Activity and Color -- 1.3. Amino Acids and Antioxidant Activity of Honey -- 1.4. Maillard Reaction Products in Honey and Antioxidant Activity -- 2. Honey Melanoidins: Composition and Antioxidant Activity -- 2.1. The Maillard Reaction and Melanoidin Formation -- 2.2. Honey Melanoidins: Honey Fractionation and Physicochemical Characterization of Fractions -- 2.3. Presence of Polyphenols in Fractions and Antioxidant Activity -- 2.4. Proteins in Fractions -- 2.5. Polyphenol-Proteins Complexes and Mechanism of Their Formation -- 3. Functional Consequence: Gain-and-Loss of Honey Function -- 3.1. Effects of the Maillard Reaction Products -- 3.2. Effects of Polyphenol-Protein Complexes -- 3.3. Effect of Honey Melanoidins on Antibacterial and Antioxidant Activities -- Conclusion -- Acknowledgments -- References -- Anticancer Activity of Honey and Its Phenolic Components -- Abstract -- 1. Introduction -- 2. Source and Compositional Chemistry of Honey -- 3. Anti-Anticancerous Property of Crude Honey -- 3.1. Role of Individual Polyphenols in Cancer.

3.1.1. Effect of Caffeic Acid and Its Esters in Animal Model and Cancer Cell Lines -- 3.1.2. Effect of Chrysin and Its Derivatives in Cancer Cell Lines -- 3.1.3. Effect of Galangin in Leukemia Cancer Cell Line -- 3.1.4. Effect of Quercetin in Cancer Cell Lines -- 3.1.5. Effect of Acacetin in Liver and Lung Cancer Cell Lines -- 3.1.6. Effect of Kaempferol in Lung and Leukemia Cells -- 3.1.7. Role of Pinocembrin and Pinobanksin in Cancer Cell Lines -- 3.1.8. Effect of Apigenin in Cancer Cells -- Conclusion -- References -- Honey and Microbes -- Abstract -- Introduction -- Microbiological Quality of Honey -- The Antimicrobial Properties of Honey -- Physico-Chemical Properties -- Phytochemical Properties of Honey -- Honey Fractions -- Variation in the Potency of the Antibacterial Activity -- The Antiviral Properties of Honey -- The Antifungal Properties of Honey -- Honey and Infection -- Honey to Prevent Wound Infections -- Honey to Treat Gastrointestinal Disorders -- Gastroenteritis -- Gastric Ulcers -- Honey for Respiratory Infections -- Honey for Eye Infections -- Honey as a Prebiotic -- Honey and Threatening Bacteria: How Safe Is Honey? -- Conclusion -- References -- Anti-Biofilm Activity of Natural Honey against Wound Bacteria -- Abstract -- Introduction -- Biofilm Susceptibility to Antimicrobial Agents -- Anti-Biofilm Strategies -- Honey -- Clinical Evidence for the Use of Honey in Management of Chronic Wounds -- Honey as an Anti-Biofilm Agent -- Inhibitory Activity of Honey in Lectin-Mediated Biofilm Formation in Pathogens -- Honey Polyphenols Disrupt Bacterial Biofilm -- Quorum Sensing Inhibitory Activity of Honey -- Materials and Methods -- Bacterial Isolates -- Antibiotic Susceptibility Test -- Honey Samples -- Minimum Inhibitory Concentration (MIC) Assay -- Test Tube Biofilm Assay -- Biofilm Inhibition Assay -- Biofilm Killing Assay.

Statistics Analysis -- Results -- Antibiotic Susceptibility Testing -- Determination of MICs of Honeys -- Biofilm Formation by Wound Isolates -- Honey and Inhibition of Biofilm Formation by Wound Isolates -- Honey and Disruption of Bacterial Biofilm -- Conclusion -- Acknowledgments -- References -- Beyond the Direct Antibacterial Activity of Honey in Wound Healing: Immunomodulatory Effects -- Abstract -- Introduction -- Honey and Immune Cells -- Honey and Monocytes/Macrophages -- Honey and Neutrophils -- Honey and Cutaneous Cells -- Conclusion -- Acknowledgments -- References -- Possible Anti-Diabetic Effects of Honey -- Abstract -- Introduction -- Appropriate Testing Methodology -- Anti-Diabetic Effects of Honey -- Studies in Diabetic Patients -- Mechanisms behind the Anti-Diabetic Effects of Honey -- Prerequisites for the Use of Honey by Diabetics -- Potential Side Effects of Honey -- Conclusion -- References -- Honey and Male Reproductive Health -- Abstract -- Introduction -- Structures and Functions of Male Reproductive Organs -- Male Reproductive Health and Honey Supplementation in Healthy Humans and Animals -- Cigarette Smoke, Oxidative Stress and Honey Supplementation on Male Reproductive Health -- Conclusion -- References -- Topical Application of Honey -- Abstract -- 1. Introduction -- 2. History of Topical Use of Honey -- 3. Epithelial and Mucosal Pathology -- 4. Microbiological Properties of Honey -- 4.1. Microbiological Profile -- 5. Tissue Repair and Wound Healing -- 5.1. Surgical Wound and Healing -- 5.2. General Wound Care -- 6. Honey in Thermal Injury -- 6.1. Practical Application of Honey on Burn Wounds -- 7. Topical Honey in Diabetic Foot -- 7.1. Practical Tips -- 8. Role of Topical Honey in Venous Leg Ulcers -- 9. Topical Application of Honey in Radiation Mucositis -- 9.1. Biological Basis of Mucositis.

9.2. Rationale of Topical Honey in Radiation Mucositis -- 9.3. Practical Application of Topical Honey in Mucositis -- 10. Topical Honey in Radiation- Induced Ulcers -- 11. Topical Honey for the Catheter Entry Site Dressing -- 12. Topical Honey in Miscellaneous Diseases -- 13. Toxicities of Topical Honey -- Conclusion -- References -- Honey in Treatment of Burn Wounds -- Abstract -- Introduction -- Etiology of Burn and Classification -- Pathophysiology of the Burn Wound -- Percentage of Burn and Outcome -- Burn Wound Infection -- Ideal Dressing for a Burn Wound -- Honey as a Topical Treament for Burn Wounds -- Mechanism of Action of Honey in Burns -- Evidence for Honey as a Topical Treatment for Burn Wounds -- Systematic Reviews of Trials of Honey in Burns -- Management of Minor Burns Using Honey -- Conclusion -- References -- The Efficacy of Honey Dressing on Chronic Wounds and Ulcers -- Abstract -- Introduction -- Patients and Methods -- Identification of Microorganisms -- Cleaning and Honey Application -- Wound Inspection -- Honeys Used in the Dressing -- Results -- Discussion -- Conclusion -- Acknowledgment -- References -- Honey for Treating Eye Diseases -- Abstract -- Introduction -- Honey as a Prophylactic Agent in Ophthalmology -- Honey and Dry Eye Syndrome -- Honey and Age-Related Eye Diseases -- Honey and Bullous Keratopathy -- Honey Polyphenolics and Eye Health -- Case Report: Treatment of a Corneal Ulcer Using Honey -- Conclusion -- Acknowledgments -- References -- Index.