STEM CELLS AND REGENERATIVE MEDICINE. VOLUME 5. PATENTS AND CLINICAL TRIALS -- STEM CELLS AND REGENERATIVE MEDICINE. VOLUME 5. PATENTS AND CLINICAL TRIALS -- Contents -- Preface -- Introduction: Therapeutic Neuronal Stem Cells: Patents at the Forefront* -- Abstract -- 1. Background -- 2. Neural Stem Cells, Therapeutic Potential and Patents -- 3. Expert Opinion -- Acknowledgments -- References** -- Chapter I Adult Neurogenesis and Pharmacology in Alzheimer's Disease and Depression -- Abstract -- Introduction -- Adult Neurogenesis in Alzheimer's Disease -- Adult Neurogenesis in Depression -- Discussion -- Conclusion and Perspectives -- Acknowledgments -- References -- Chapter II Adult Neurogenesis in the Pathogenesis of Alzheimer's Disease -- Acknowledgments -- References -- Chapter III Therapeutic Potential of Adult Neural Stem Cells* -- Abstract -- Introduction -- Neural Progenitor and Stem Cells -- Neural Progenitor and Stem Cells in Vitro -- Origin of Newly Generated Neuronal Cells in the Adult Brain -- Therapeutic Potential of Adult NSCs -- Cellular Therapy -- Gene Therapy -- Current and Future Developments -- References** -- Chapter IV Human Neural Progenitor and Stem Cells* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Proliferation Medium -- 2.2 Culture of Human Fetal Neural Progenitor and Stem Cells -- 3. Biology and Action -- 3.1 Growth Rate -- 3.2 Immunocytofluorescence -- 3.3 Differentiation of Human Fetal Neural Progenitor and Stem Cells -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter V Cryopreservation of Early Postmitotic Neuronal Cells in Culture* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Defined Derivation Medium -- 2.1.1 Defined Derivation Medium #1 -- 2.1.2 Defined Medium #2 -- 2.1.3 Defined Medium #3 -- 2.2 Induction Medium -- 2.2.1 Induction Medium.

2.3 Production of Neural Progenitor Cells from Embryonic Stem Cells -- 2.4 Induction of Neural Progenitor Cells into Neuronal or Neural-Like Cells -- 2.5 Cryopreservation -- 2.6 Thawing Cryopreserved Cells -- 2.7 Cultivation -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VI Adult Neural Stem Cells for the Treatment of Neuroinflammation* -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 3.1 Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis -- 3.2 Syngeneic Transplantation -- 3.3 In Situ Proliferation of Transplanted Anscs -- 3.4 Immunocytology and Immunohistology -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VII Adult Periodontal-Derived Neural Progenitor and Stem Cells* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Periodontal Tissue -- 2.2 Cell Culture -- 2.3 Differentiation -- 2.4 Immunocytology -- 2.5 Organotypic Hippocampal Slice Cultures -- 2.6 Further Studies -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter VIII Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Experimental Study in Rats -- 2.2 MRI Scanning in Rats -- 2.3 Histology -- 2.4 Epidemiological Study -- 2.5 MRI Protocol in Human Subjects -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter IX Apigenin and Related Compounds Stimulate Adult Neurogenesis* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Compounds and Derivatives -- 2.2 Synthesis -- 3. Biology and Action -- 3.1 Animal Studies -- 3.1.1 Intraperitoneal Administration of Apigenin -- 3.1.2 Oral Administration of Apigenin and Epicatechin -- 3.2 Immunohistology -- 3.3 Cell Culture -- 4. Expert Opinion -- Acknowledgments.

References** -- Chapter X Nootropic Agents Stimulate Neurogenesis* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Cell Culture -- 2.2 Differentiation -- 2.3 Immunocytochemistry -- 2.4 Novel Object Recognition Task -- 3. Biology and Action -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XI Fourteen Compounds and their Derivatives for the Treatment of Diseases and Injuries Characterized by Reduced Neurogenesis and Neurodegeneration* -- Abstract -- 1. Introduction -- 2. Chemistry -- 2.1 Compounds and Derivatives -- 2.2 Synthesis -- 3. Biology and Action -- 3.1 Cell Culture -- 3.2 Immunocytology -- 3.3 Apoptosis -- 3.4 Necrosis -- 3.5 Neuron Dysfunction -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XII Brevetoxin Derivative Compounds for Stimulating Neuronal Growth* -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 3.1 Primary Cell Culture of Neocortical Neurons -- 4. Expert Opinion -- Acknowledgments -- References** -- Chapter XIII OTI-010 Osiris Therapeutics/JCR Pharmaceuticals* -- Summary -- Abstract -- Introduction -- Synthesis and SAR -- Preclinical Development -- In Vitro -- In Vivo -- Toxicity -- Clinical Development -- GVHD -- Transplantation in Cancer Patients -- Crohn's Disease -- Metabolism and Pharmacokinetics -- Side Effects and Contraindications -- Patent Summary -- Current Opinion -- Licensing -- JCR Pharmaceuticals Co Ltd -- Acknowledgments -- References -- Chapter XIV ADA-Transduced Hematopoietic Stem Cell Therapy for ADA-SCID -- Summary -- Abstract -- Introduction -- Synthesis and SAR -- Preclinical Development -- Metabolism and Pharmacokinetics -- Toxicity -- Clinical Development -- Phase I/II -- Side Effects and Contraindications -- Patent Summary -- Current Opinion -- Acknowledgments -- References* -- Index.