BIODEGRADABLE COMPOSITES FOR BONE REGENERATION -- BIODEGRADABLE COMPOSITES FOR BONE REGENERATION -- CONTENTS -- PREFACE -- ABSTRACT -- Chapter 1 INTRODUCTION -- PRINCIPLES OF TISSUE ENGINEERING -- BIOCOMPATIBILITY TESTING OF MEDICAL DEVICES: "TESTS FOR IN VITRO CYTOTOXICITY (EN ISO 10993-5)" -- PRINCIPLES OF SYNTHETIC BONE SUBSTITUTES -- POLYMERS FOR BONE TISSUE ENGINEERING -- SILICA-BASED MATERIALS AND NANOPARTICLES FOR BONE REGENERATION -- THE USE OF CALCIUM SULPHATE IN BONE REGENERATION -- Chapter 2 REALIZATION AND PERFORMANCE ANALYSIS OF PCL/ SILICA NANOCOMPOSITES FOR BONE REGENERATION -- MECHANICAL ALLOYS (CHEMICAL PHYSICAL AND MECHANICAL PROPERTIES) -- CHEMICAL MODIFICATION AND CHARACTERIZATION OF NANOCOMPOSITES -- MORPHOLOGIC ANALYSIS (SEM) -- BIOLOGICAL EVALUATION -- Conclusion -- EXPERIMENTAL -- Materials -- PREPARATION OF SILICA NANOPARTICLES -- PREPARATION OF NANOCOMPOSITES -- A. Mechanical Alloys -- B. Functionalised Nanocomposites -- DIFFERENTIAL THERMAL ANALYSIS (DSC) -- Mechanical Tests -- SCANNING AND TRANSMISSION ELECTRON MICROSCOPY (SEM AND TEM) -- Elution Test -- PREPARATION AND CHARACTERIZATION OF BONE MARROW MSCS -- DIRECT CONTACT TEST -- MTT Test -- ALKALINE PHOSPHATASE ASSAY -- OSTEOCALCIN SYNTHESIS -- STATISTICAL ANALYSIS -- Chapter 3 NOVEL INJECTABLE ALGINATE/ N-SUCCINYLCHITOSAN/CALCIUM SULPHATE COMPOSITES AS BONE-DEFECTS FILLERS -- BIOLOGICAL EVALUATION -- Conclusion -- EXPERIMENTAL -- Materials -- PREPARATION OF N-SUCCINYLCHITOSAN -- MECHANICAL TESTS -- OSTEOGENIC MARKERS (AP, OC) EVALUATION -- EXTRACELLULAR MATRIX MINERALIZATION -- REFERENCES -- INDEX.