PROTEOMICS: METHODS, APPLICATIONS AND LIMITATIONS -- PROTEOMICS: METHODS, APPLICATIONS AND LIMITATIONS -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- CONTENTS -- PREFACE -- Chapter 1: PROTEOMICS IN CELIAC DISEASE -- ABSTRACT -- PROTEOMIC APPROACHES -- QUANTIFICATION OF GLIADIN AND GLIADIN-DERIVED EPITOPES BY MASS SPECTROMETRY -- HUMAN BODY FLUID PROTEOME ANALYSIS -- CONCLUSION -- REFERENCES -- Chapter 2: THE PUZZLE OF PROTEIN LOCATION IN PLANT PROTEOMICS -- ABSTRACT -- INTRODUCTION -- ORGANELLE ISOLATION -- ORGANELLES SURROUNDED BY DOUBLE MEMBRANES -- PROTEIN LOCATION -- BIOINFORMATIC PREDICTIONS -- EXPERIMENTAL LOCATION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3: WHAT FUTURE FOR"GEL-BASED PROTEOMIC" APPROACHES? -- ABSTRACT -- 1 - INTRODUCTION -- 2 - THE STATE OF THE ART OF "GEL-BASED PROTEOMIC" APPROACHES -- 3 - RECENT ADVANCES IN "GEL-BASED PROTEOMIC" APPROACHES: DIFFERENCE IN GEL ELECTROPHORESIS (2D-DIGE) -- 4 - BENEFITS OF "GEL-BASED PROTEOMIC" APPROACHES: CHARACTERIZATION OF PROTEIN ISOFORMS -- 5 - LIMITS AND ANSWERS OF"GEL-BASED PROTEOMIC" APPROACHES -- 6 - WHAT FUTURE FOR "GEL-BASED PROTEOMIC" APPROACHES? -- REFERENCES -- Chapter 4: ALGORITHMS FOR THE QUANTIFICATION OF PROTEINS FROM HIGH-THROUGH PUT LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS)DATA -- Abstract -- 1. Introduction -- 2. Instrumentation -- 3. AlgorithmsforQuantitativeLC-MS Experiments -- 4. Summary and Conclusions -- References -- Chapter 5: METHOD FOR PREDICTION OF PROTEIN-PROTEIN INTERACTIONS IN YEAST USING GENOMICS/PROTEOMICS INFORMATION AND FEATURE SELECTION -- Abstract -- 1. Introduction -- 2. Feature Extraction -- 3. Feature Selection -- 4. Support Vector Machines -- 5. Results -- 6. Conclusions -- Acknowledgments -- References -- Chapter 6: LABEL-FREE LIQUID CHROMATOGRAPHY-BASED QUANTITATIVE PROTEOMICS: CHALLENGES AND RECENT DEVELOPMENTS.

ABSTRACT -- RECENT METHODS USED IN QUANTITATIVE PROTEOMICS -- SAMPLE PREPARATION -- ENHANCED DATA QUALITY BY IMPROVED LC-SEPARATION -- COMPUTATIONAL METHODS FOR COMPARATIVE PROFILING -- MULTIVARIATE STATISTICS FOR COMPARATIVE PROTEOMICS AND KINETIC ANALYSES -- DATABASES AND SEARCH ALGORITHMS -- PERSPECTIVES -- CONCLUSIONS -- REFERENCES -- Chapter 7: INSIGHTS FROM PROTEOMICS INTO MILD COGNITIVE IMPAIRMENT, LIKELY THE EARLIEST STAGE OF ALZHEIMER'S DISEASE -- ABSTRACT -- 1. INTRODUCTION -- 2. TWO-DIMENSIONAL (2D) GEL ELECTROPHORESIS (GE) BASED PROTEOMICS -- 3. CANDIDATE BIOMARKERS IN CSF FOR THE PROGRESSION OF MCI TO AD -- 4. PROTEOMICS ANALYSES OF BRAIN FROM MCI PATIENTS -- 5. REDOX PROTEOMICS ANALYSES OF BRAIN FROMMCI PATIENTS -- 6. CONCANAVALIN-A ASSOCIATED GLYCOPROTEINS IN BRAIN REGIONS FROM MCI PATIENTS -- 7. CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 8: MULTIDIMENSIONAL CHROMATOGRAPHY:AN ESSENTIAL TOOL FOR PROTEOMICS -- ABSTRACT -- WHY MULTI DIMENTIONAL LIQUID CHROMATOGRAPHY IN PROTEOMIC ANALYSIS? -- PROTEINS OR PEPTIDES LEVEL SEPARATION? -- MULTIDIMENSIONAL CHROMATOGRAPHIC TECHNIQUES -- CONCLUSION -- REFERENCES -- Commentary: PROTEOMIC APPROACH IN ANALYSING CARDIAC RESPONSES ON LOW-DOSEIONISING RADIATION USING CELLULAR AND TISSUE MODELS -- REFERENCES -- INDEX -- Blank Page.