NEURAL STEM CELLS AND CELLULAR THERAPY -- NEURAL STEM CELLS AND CELLULAR THERAPY -- Contents -- Introduction Adult Neural Stem Cells: The Promise of the Future -- Abstract -- Introduction -- Adult Neurogenesis, Facts and Debates -- The Future of Adult Neurogenesis -- The Promise of Adult Neural Stem Cells -- Conclusion -- Acknowledgments -- References -- Neurogenesis in the Adult Central Nervous System -- Abstract -- Introduction -- Neurogenesis in the Adult Brain -- Neural Progenitor and Stem Cells from the Adult Brain -- Neural Progenitor and Stem Cells in the Adult Brain -- A Developmental Process -- Redefining CNS Physiopathology -- Cellular Therapy in the Adult CNS -- Concluding Remarks -- Acknowledgments -- References -- BrdU Immunohistochemistry for Studying Adult Neurogenesis: Paradigms, Pitfalls, Limitations and Validation -- Abstract -- 1. Introduction -- 2. Adult Neurogenesis -- 3. Strategies for Studying Adult Neurogenesis -- 4. Assessment of BrdU Labeling for Studying Cell Proliferation and Adult Neurogenesis -- 5. Concluding Remarks -- Acknowledgments -- References -- Adult Neural Stem Cells, Neurogenic Niches and Cellular Therapy -- Abstract -- Introduction -- Adult Neurogenesis and NSCs -- Neurogenic Niches -- Broader Potential of Adult Stem Cells -- Cellular Therapy -- Conclusion -- Acknowledgments -- References -- Neurogenic Factors are Targets in Depression -- Abstract -- Introduction -- Adult Neurogenesis and Depression -- Adult Neurogenesis and the Pharmacology of Depression -- Discussion -- Conclusion -- Acknowledgments -- References -- Adult Neurogenesis, Neural Stem Cells and Alzheimer's Disease: Developments, Limitations, Problems and Promises∗ -- Abstract -- Introduction -- Alzheimer's Disease Pathology and Pathogenesis -- Discussion -- Conclusion and Perspectives -- References.

Adult Neurogenesis Pharmacology in Neurological Diseases and Disorders -- Abstract -- Key Issues -- Introduction -- Neurogenesis in the Adult Brain -- Neurogenesis in Neurological Diseases and Disorders -- Neurogenesis and the Etiology of Neurological Diseases and Disorders -- Pharmacology of Adult Neurogenesis -- Discussion -- Expert Commentary and Five-Year View -- Financial and Competing Interests Disclosure -- Acknowledgments -- References -- Adult Neural Stem Cells: A Promising Candidate for Regenerative Therapy in the CNS -- Abstract -- Introduction -- Fetal Neuronal Cells -- Paracrine Systems -- Stem Cells -- Conclusion -- Acknowledgments -- References -- Stem Cells Engineering for Cell-Based Therapy -- Abstract -- Introduction -- Cell Engineering to Derive ESCs without the Destruction of Embryos -- Adult Neural Stem Cell Engineering -- Conclusion -- Acknowledgments -- References -- Therapeutic Neuronal Stem Cells: Patents at the Forefront -- Abstract -- 1. Background -- 2. Neural Stem Cells, Therapeutic Potential and Patents -- 3. Expert Opinion -- Declaration of Interest -- Acknowledgments -- References -- Adult Neural Stem Cells for the Treatment of Neuroinflammation -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 4. Expert Opinion -- Declaration of Interest -- Acknowledgments -- References -- Magnetic Resonance Imaging for Monitoring Neurogenesis in the Adult Hippocampus -- Abstract -- 1. Introduction -- 2. Chemistry -- 3. Biology and Action -- 4. Expert Opinion -- Declaration of Interest Statement -- Acknowledgments -- References -- HuCNS-SC StemCells -- Abstract -- Summary -- Introduction -- Synthesis and SAR -- Preclinical Development -- Metabolism and Pharmacokinetics -- Toxicity -- Clinical Development -- Side Effects and Contraindications -- Patent Summary -- Current Opinion -- Licensing.

Development History -- Acknowledgments -- References -- Conclusion and Perspectives Adult Neural Stem Cells from Promise to Treatment: The Road Ahead -- Acknowledgments -- References -- Index.