PHYSIOLOGY AND MEDICINE -- PHYSIOLOGY AND MEDICINE -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- CONTENTS -- DISCLAIMER -- FOREWORD -- PREFACE -- INTRODUCTION -- REFERENCES -- Chapter I: SYSTEMS WITHIN THE SYSTEMS WITHIN THE SYSTEMS -- A HISTORICAL PERSPECTIVE -- THE LEVELS OF THE PHYSIOLOGICAL SYSTEMS -- DISEASE ETIOLOGY AND MEDICAL DIAGNOSTICS -- Primary vs. Secondary Origin of Disease -- The Role of Complete Diagnostics -- Understanding the Basic Physiology Behind the Disease -- CHAPTER SUMMARY -- REFERENCES -- Chapter II: SOME BASICS OF CARDIOVASCULAR PHYSIOLOGY, PATHOLOGY AND GENETICS -- CVD: CARDIOVASCULAR DISEASE -- FACTORS OF CARDIOVASCULAR RISK -- Environmental Factors -- Dietary Factors -- Physical Exercise -- Microbiological Factors -- Psychological Factors -- BIOCHEMICAL MARKERS AND DIAGNOSTICS OF CVD: A FEW EXAMPLES -- Fibrinogen Test for a Long-term Prognosis -- C-reactive Protein for Long-term Prognosis -- D-dimer and DVT Diagnostics -- APPROACHING CVD GENETICS -- CVD GENETICS AND BIOINFORMATICS -- The Cardiovascular Biochemical Variables -- Published Data of Genotype-phenotype Association Studies -- THE CASE OF A GENESCAPE FOR CVD -- Introduction -- Methods -- Results -- AN ULTRA-BRIEF OVERVIEW OF THE CVD GENETICS -- CHAPTER SUMMARY -- REFERENCES -- Chapter III: BIOMEDICAL STUDIES AND THE STUDIES OF THE STUDIES -- THE INFORMATIONAL OVERLOAD IN MODERN HUMAN PHYSIOLOGY -- SEARCH FOR AND RETRIEVAL OF STUDIES -- ASSESSMENT OF BIOMEDICAL STUDIES -- STUDY ASSESSMENT: THE USE OF HIERARCHIES -- STUDY ASSESSMENT: QUESTIONNAIRES -- STUDY ASSESSMENT: APPRAISAL OF OBSERVATIONAL STUDIES -- STUDY ASSESSMENT: THE STUDY COHORTS -- STUDY ASSESSMENT: STATISTICAL ASPECTS -- STUDY ASSESSMENT: A FORGERY? -- ANALYZING A COHORT -- THE CASE OF IHD200 -- Introduction -- Materials and Methods -- Results -- CHAPTER SUMMARY -- REFERENCES.

Chapter IV: MEDSNP: A MIDDLE GROUND BETWEEN PHYSIOLOGY, GENETICS AND MEDICINE -- TESTING GENETIC RISKS -- MEDSNP™: A DATABASE FOR CLINICAL APPLICATIONS IN GENOMIC MEDICINE -- MAKING THE DATABASE -- PRELIMINARY DATABASE ANALYSIS: SELECTING THE STUDIES AND THE POLYMORPHISMS -- EXPLORING MEDSNP: A BRIEF LOOK -- CHAPTER SUMMARY -- REFERENCES -- Chapter V: GENETIC ASSOCIATIONS: ANALYSES OF THE DATA CONSISTENCY -- INTRODUCTION -- META-ANALYSIS -- ORTHO-ANALYSES? -- ORTHO-ANALYSIS: CONSISTENCY ACROSS THE LEVELS OF FUNCTION -- ORTHO-ANALYSIS: QUANTITATIVE ANALYSES OF BIOCHEMICAL VARIABLES -- ORTHO-ANALYSIS: DOSE-DEPENDENT EFFECTS -- ORTHO-ANALYSIS: MULTIVARIATE VS. UNIVARIATE -- ORTHO-ANALYSIS: QUALITATIVE ANALYSES OF HETEROGENEOUS CLINICAL STUDIES -- PARA-ANALYSIS: TAKING A LOOK AT FAILURES -- PARA-ANALYSIS: A2M INS/DEL AND THE RISK OF ALZHEIMER DISEASE -- PARA-ANALYSIS: SUBSTANTIATED NEGATIVE REPORTS -- ANALYSES OF DATA CONSISTENCY AND IMPLICATIONS FOR POST-GENOMIC STUDIES -- CHAPTER SUMMARY -- REFERENCES -- Chapter VI: THE FUNCTIONAL GENOMICS QUEST -- INTRODUCTION -- ON "FUNCTIONAL GENOMICS" AND "SYSTEMS BIOLOGY" -- AIMING AT COMPLEX DISEASES -- AIMING AT COMPLEX DISEASES: THE SCLERODERMA EXAMPLE -- THE CASE OF SCLERODERMA GENESCAPE, -- Introduction -- Methods -- Results -- AIMING AT COMPLEX DISEASES: CVD -- IDENTIFICATION OF THE TARGET GENES: TRANSCRIPTOMICS -- IDENTIFICATION OF THE TARGET GENES: PROTEOMICS -- THE CASE OF ESTROGENS AND VENOUS THROMBOSIS -- ESTROGENS AND VENOUS THROMBOSIS: AN EXTENDED DISCUSSION -- ESTROGENS AND VENOUS THROMBOSIS: SUGGESTIONS FOR FUNCTIONAL GENOMICS STUDIES -- CHAPTER SUMMARY -- REFERENCES -- Chapter VIIL METABOLIC PATHWAYS AND MOLECULAR CASCADES -- INTRODUCTION -- MOLECULAR CASCADES, METABOLIC PATHWAYS AND METABOLIC CONTEXTS -- THE CASE OF A METABOLIC CONTEXT RECONSTRUCTION (MTHFR).

METABOLIC CONTEXT ANALYSIS AND MOLECULAR MECHANISMS OF HUMAN DISEASE -- MATHEMATICAL MODELING OF METABOLIC PATHWAYS AND MOLECULAR CASCADES -- NETWORK APPROACHES TO MOLECULAR CASCADES -- IN SILICO INTERACTOMICS: AN INQUIRY -- Introduction -- Methods -- Results -- Conclusions -- IN SILICO INTERACTOMICS: SOME PERSPECTIVES -- INTERACTOMICS:WHERE CAN WE GO? -- CHAPTER SUMMARY -- REFERENCES -- Chapter VIII: METABOLOME ANALYSES AND DRUG DESIGN -- INTRODUCTION -- METABOLOMICS: A REVIEW -- A FEW PATHWAY DATABASES -- MALARIA: THE CURRENT SITUATION -- MALARIA: POST-GENOMIC STUDIES -- THE CASE OF MALARIA DRUGS AND IN SILICO METABOLOMICS -- Introduction -- Methods -- Results -- MALARIA: INVOLVING BIOINFORMATICS -- CHAPTER SUMMARY -- REFERENCES -- CONCLUSION -- REFERENCES -- APPENDIX I. CVD GENESCAPE DIAGRAM: THE BRIEF DESCRIPTIONS OF THE GENES -- THE GENE DESCRIPTIONS -- INDEX.