THE CONCEPTUAL FOUNDATIONS OF SYSTEMS BIOLOGY: AN INTRODUCTION -- THE CONCEPTUAL FOUNDATIONS OF SYSTEMS BIOLOGY: AN INTRODUCTION -- CONTENTS -- ACKNOWLEDGMENTS -- PREFACE -- WHAT IS SYSTEMS BIOLOGY? -- HISTORY OF SYSTEMS BIOLOGY -- Revolutionary Reconstruction -- Evolutionary Reconstruction -- DEFINING SYSTEMS BIOLOGY -- Revolutionary Definitions -- Evolutionary Definitions -- CONCLUSION -- REDUCTIONISM OR HOLISM? -- WHAT IS REDUCTIONISM? -- Ontological Reductionism -- Methodological Reductionism -- Epistemological Reductionism -- Summary -- WHAT IS HOLISM? -- Ontological Holism -- Methodological Holism -- Epistemological Holism -- Summary -- CONCLUSION -- MECHANISM OR EMERGENTISM? -- WHAT IS MECHANISM? -- Defining Mechanism -- DNA Transcription -- Synthesis -- Summary -- WHAT IS EMERGENTISM? -- Defining Emergentism -- Characteristics of Emergentism -- Categories of Emergentism -- Synergism -- Summary -- CONCLUSION -- HOMEOSTASIS OR ROBUSTNESS? -- WHAT IS HOMEOSTASIS? -- Defining Homeostasis -- Homeostatic Mechanisms -- Summary -- WHAT IS ROBUSTNESS? -- Defining Robustness -- Robustness Architecture -- Evolvability -- Fragility -- Summary -- CONCLUSION -- WHAT TYPE OF SYSTEMS DISEASE IS CANCER? -- A MOLECULAR SYSTEMS DISEASE? -- Reductionism -- Mechanism -- Homeostasis -- Summary -- A TISSUE SYSTEMS DISEASE? -- Holism -- Emergentism -- Robustness -- Summary -- A MOLECULAR/TISSUE SYSTEMS DISEASE? -- Heterotypic Cell Biology Model and Hallmarks of Cancer -- Dynamic Reciprocity Model -- Summary -- CONCLUSION -- WHAT ARE THE CHALLENGES FACING SYSTEMS AND CANCER BIOLOGY? -- METHODOLOGICAL CHALLENGES -- Technological Challenges -- Computational Challenges -- CONCEPTUAL CHALLENGES -- SOCIAL CHALLENGES -- ETHICAL CHALLENGES -- CANCER SYSTEMS BIOLOGY CHALLENGES -- CONCLUSION -- IS SYSTEMS BIOLOGY A SCIENTIFIC REVOLUTION? -- NORMAL SCIENCE.

SCIENTIFIC REVOLUTIONS -- CONCLUSION -- REFERENCES -- INDEX.