STEM CELLS AND REGENERATIVE MEDICINE VOLUME VII DISEASES AND THERAPY -- STEM CELLS AND REGENERATIVE MEDICINE VOLUME VII DISEASES AND THERAPY -- Contents -- Introduction Adult Neurogenesis and Neural Stem Cells: Developmental and Therapeutic Potential -- Acknowledgments -- Chapter I Enhanced Neurogenesis following Neurological Disease -- Abstract -- Adult Neurogenesis in Alzheimer's Disease and in Neurodegenerative Diseases of the Brain -- Huntington's Disease -- Parkinson's Disease -- Adult Neurogenesis in Epilepsy -- Function of the Newly Generated Neuronal Cells in Neurological Diseases -- Therapy -- Stimulation of Endogenous Neural Progenitor Cells -- Transplantation -- Conclusions -- Acknowledgments -- References -- Chapter II Alzheimer's Disease: Increased Neurogenesis and Possible Disease Mechanisms Related to Neurogenesis -- Etiology and Pathology of Alzheimer' s Disease -- Amyloid Plaques and Neurofibrillary Tangles -- Genetic Factors and Mutations -- Aneuploidy -- Enhanced Neurogenesis -- Possible Mechanisms Related to Adult Neurogenesis -- Aneuploidy in AD Patients -- Aneuploidy for Chromosome 21 and Amyloid Deposits -- Aneuploidy for Chromosome 17 and Neurofibrillary Tangles Formation -- Aneuploidy for Chromosomes 1, 14 and 19 and Pathogenesis of AD -- Aneuploidy and Adult Neurogenesis -- Factors Promoting Aneuploidy in Alzheimer's Disease -- Hyperphosphorylation of Tau Protein -- Mutation in PSEN1 -- Modulation of Adult Neurogenesis -- Oxidative Stress -- Conclusion and Perspectives -- Acknowledgments -- References -- Chapter III Neurogenesis, NSCs, Pathogenesis and Therapies for Alzheimer's Disease -- Abstract -- Abbreviations -- Introduction -- Adult Neurogenesis and Neural Stem Cells -- Neurogenesis in the Adult Brain of Mammals -- Neural Progenitor and Stem Cells In Vitro.

Modulation of Adult Neurogenesis In Vivo -- Cellular Therapy -- Alzheimer's Disease -- A Senile Dementia and Neurodegenerative Disease -- Amyloid Plaques and Neurofibrillary Tangles -- Genetic Mutations and Risks Factors in Alzheimer's Disease -- Aneuploidy in Region of Neurodegeneration -- Adult Neurogenesis and the Pathogenesis of Alzheimer's Disease -- Neurogenesis in Alzheimer's Disease -- Aneuploid Newly Generated Neuronal Cells in the Adult Brain with Alzheimer's Disease -- Novel Drug Targets for Alzheimer's Disease -- Newly Generated Neuronal Cells of the Adult Brain -- Aneuploid Newly Generated Neuronal Cells of the Adult Brain -- Summary and Perspectives -- Acknowledgments -- References -- Chapter IV Adult Neurogenesis and Drug Therapy* -- Abstract -- Introduction -- Neurogenesis in the Adult Mammalian Brain -- Neurogenesis and Neurological Diseases, Disorders and Injuries -- Neurogenesis in Neurodegenerative Diseases and Disorders -- Neurogenesis and Injuries -- Discussion -- Stimulation of Neurogenesis -- Drug Therapy -- Conclusion -- References -- Chapter V Neurogenic Factors Are Targets in Depression -- Abstract -- Introduction -- Adult Neurogenesis and Depression -- Adult Neurogenesis and the Pharmacology of Depression -- Discussion -- Adult Neurogenesis and Depression -- The Hippocampus and Depression -- Limitations of Paradigms and Models to Study Adult Neurogenesis and Depression -- Conclusion -- Acknowledgments -- References -- Chapter VI Pharmacology of Adult Neurogenesis: Compensatory and Regenerative Processes -- Introduction -- Pharmacology of Adult Neurogenesis in Alzheimer's Disease -- Alzheimer's Disease and Drug Therapy -- Adult Neurogenesis and Alzheimer's Disease Drugs -- Pharmacology of Adult Neurogenesis in Depression -- Depression and Antidepressants -- Adult Neurogenesis and Antidepressants -- Discussion.

Drug Therapy: Compensatory Processes -- Adult Neurogenesis in Neurological Diseases and Disorders: Regenerative Processes -- Adult Neural Stem Cells and Regenerative Medicine -- Conclusion and Perspectives -- Acknowledgments -- References -- Chapter VII Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells -- Abstract -- Introduction -- Neurogenesis and Neural Stem Cells in the Adult CNS -- Adult Neurogenesis in Neurological Diseases and Disorders -- Alzheimer's Disease -- Depression -- Epilepsy -- Huntington's Disease -- Parkinson's Disease -- Therapeutic Potential of Adult Neural Stem Cells -- Stimulation of Neural Progenitor or Stem Cells of the Adult CNS -- Transplantation of Neural Progenitor and Stem Cells of the Adult CNS -- Neuroinflammation and the Therapeutic Potential of Adult NSCs -- Neuroin ammation in Neurological Diseases and Injuries -- Neuroin ammation in Adult Neurogenesis -- Neuroin ammation and Neural Progenitor and Stem Cell Transplantation -- Limitations and Pitfalls of BrdU Labelling for Studying Neurogenesis -- Conclusions and Perspectives -- Acknowledgments -- References -- Chapter VIII A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and Alzheimer's Disease* -- Abstract -- Introduction -- Alzheimer's Disease Is Caused by Excessive Rate of Genome Damage -- Enhanced Neurogenesis in Alzheimer's Disease -- Oxidative Stress Contributes to the Pathogenesis of Alzheimer's Disease -- A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and on the Pathogenesis of Alzheimer's Disease -- ROS and Oxidative Stress Control the Cell Cycle and Genomic Stability -- Concluding Remarks -- References -- Chapter IX Adult Neurogenesis and Neural Stem Cells as a Model for the Discovery and Development of Novel Drugs -- Abstract -- Introduction.

Adult Neurogenesis and Drugs to Treat Neurological Diseases and Disorders -- Adult Neurogenesis and NSCs Are Targets of Drugs Used for Treating Neurological Diseases and Disorders -- Neurogenic Drugs to Reverse or Compensate Deficits and Impairments Associated with the Hippocampus -- Expert Opinion -- Adult NSCs: A Promising Model to Discover and Develop Neurogenic Drugs -- Limitations and Pitfalls of Adult NSCs for Discovering and Developing Neurogenic Drugs -- Declaration of Interest -- Acknowledgments -- Bibliography -- Chapter X Neurogenic Drugs and Compounds* -- Abstract -- Introduction -- Recent patents on Compounds and Drugs Modulating Neurogenesis in the Adult Brain Nootropic Agents -- The Activity of 15 Compounds and their Derivatives -- Apigenin and Related Compounds -- Discussion -- Current and Future Developments -- Conflict of Interest -- References -- Chapter XI Very Small Embryonic-like Stem Cells for Regenerative Medicine* -- Abstract -- Background -- Methods -- Results -- Introduction -- Chemistry -- Biology and Action -- Expert Opinion -- Declaration of Interest -- Acknowledgments -- References -- Chapter XII Transplantation of Cord Blood Stem Cells for Treating Hematologic Diseases and Strategies to Improve Engraftment -- Executive Summary -- Abstract -- Introduction -- HSCs and Cord Blood Stem Cells -- Selectins and the Homing of HSCs -- P- and E-selectins and Selectin Glycoprotein Ligands -- Homing of Hematopoietic Progenitor and Stem Cells of the BM and CB -- Transplantation of Cord Blood Stem Cells for the Treatment of Hematologic Diseases -- Total Nucleated Cell Count and Age of Patients -- Early Infections and Delayed Engraftment -- Graft-versus-Host Disease -- Strategies to Improve the Outcome of CB Transplantation for the Treatment of Hematologic Diseases.

Direct Delivery of Cord Blood Stem Cells to the Bone Marrow -- Transplantation of Double Cord Blood Units -- Fucosylation of Selectin Glycoprotein Ligands Ex Vivo -- Expansion and Propagation of Cord Blood Stem Cells In Vitro -- Conclusion -- Future Perspectives -- Financial and Competing Interests Disclosure -- Acknowledgments -- References -- Chapter XIII Transplantation of Two Populations of Stem Cells to Improve Engraftment* -- Abstract -- Background -- Methods -- Results -- Conclusion -- Introduction -- Methods -- Transplant -- Transplantation -- Biology and Action -- Expert Opinion -- Declaration of Interest -- Acknowledgments -- Bibliography -- Chapter XIV Ex Vivo Fucosylation of Stem Cells to Improve Engraftment* -- Abstract -- Background -- Objective -- Methods -- Results -- Conclusion -- Introduction -- Biology and Action -- In Vivo and In Vitro Studies -- Fucosyltransferases -- Expert Opinion -- Declaration of Interest -- Acknowledgments -- Bibliography -- Chapter XV Thirteen Compounds Promoting Oligodendrocyte Progenitor Cell Differentiation and Remyelination for Treating Multiple Sclerosis -- Abstract -- Background -- Objective -- Methods -- Results -- Conclusion -- Introduction -- Chemistry and Synthesis -- Biology and Action -- Culture of Oligodendrocyte Progenitor Cells -- Cerebellar Organotypic Cultures and Lysolecithin Demyelination -- Zebrafish Model -- Cuprizone-mediated Demyelination Mouse Model -- Other Assays -- Drug Screenings -- Primary Screening -- Secondary Screening -- Expert Opinion -- Declaration of Interest -- Acknowledgments -- Bibliography -- Chapter XVI Antibodies against CD20 (Rituximab) for Treating Multiple Sclerosis -- Abstract -- Background -- Objective -- Methods -- Conclusion -- Introduction -- Chemistry and Synthesis -- Biology and Action -- Expert Opinion -- Declaration of Interest -- Acknowledgments.

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