TYPE I COLLAGEN: BIOLOGICAL FUNCTIONS, SYNTHESIS AND MEDICINAL APPLICATIONS -- TYPE I COLLAGEN: BIOLOGICAL FUNCTIONS, SYNTHESIS AND MEDICINAL APPLICATIONS -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter I: COLLAGEN TYPE I: A PROMISING SCAFFOLD MATERIAL FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE -- ABSTRACT -- INTRODUCTION -- COLLAGENS AS RAW MATERIALS -- Extracted Collagens -- Collagen Biosynthesis -- Recombinantly Produced Collagen -- COLLAGEN AS A BIOMATERIAL -- COLLAGEN CROSSLINKING -- TISSUE ENGINEERING APPLICATIONS -- Hemostasis -- Bone -- Cartilage -- Cornea -- Cardiovascular -- Nerve Tissue -- Therapeutic Agents Delivery -- CONCLUSION -- REFERENCES -- Chapter II: DEGRADATION OF TYPE I COLLAGEN AND PATHOGENESIS OF INFECTIOUS DISEASES -- ABSTRACT -- INTRODUCTION -- METALLOPROTEASE COLLAGENASES -- Matrix Metalloproteases -- M9 Bacterial Collagenases -- NON-METALLOPROTEASE COLLAGENASES -- Serine Proteases -- Cysteine Proteases -- HUMAN PATHOGENS VERSUS COLLAGEN DEGRADATION -- CONCLUSION -- REFERENCES -- Chapter III: TYPE I COLLAGEN AND ITS UTILITYAS SPECIFIC BONE MARKER -- ABSTRACT -- BACKGROUND -- TYPE I COLLAGEN -- Clinical Use of C- and N-Propeptides -- AGEING MOLECULAR CHANGES IN THE STRUCTURAL COMPONENTS TYPE I COLLAGEN -- 1. Lysyl Oxidase-Derived Cross-Links -- 2. Non-Enzymic Glycosylation-Derived Cross-Links (Glycation) -- COLLAGEN BREAKDOWN -- CONCLUSION -- REFERENCES -- Chapter IV: DEVELOPMENT OF 3-D COLLAGEN GEL VASCULARIZED TISSUE-ENGINEERED CONSTRUCTS FOR BONE REPLACEMENT AND REGENERATION USING EMBRYONIC AND POSTNATAL PROGENITORS -- ABSTRACT -- 1. INTRODUCTION -- 2. SIGNIFICANCE AND ROLE OF ECM MATERIALS DURING TISSUE REGENERATION AND DEVELOPMENT -- 3. EXPERIMENTAL APPROACH -- 4. RESEARCH METHODS -- 4.1. Fabrication of Tubular Scaffold.

4.2. BMSCs isolation, Expansion and Maintenance (Nonclonal BMSC Culture) -- 4.3. Immunophenotyping of BMSCs by Flow Cytometry and Confocal Microscopy -- 4.4. Purification and Enrichment of CD90+ BMSCs by Magnetic-activated Cell Sorting (MACS) -- 4.5. BMSCs Osteoblastic Differentiation -- 4.6. Quail PE Isolation and BMSCs/PEs Co-culture -- 5. BMSCS AND BMSCS/PES BASED VASCULARIED BONE REGENERATION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter V: COLLAGEN I SYNTHESIS, BIOLOGICAL FUNCTIONS AND MEDICAL APPLICATIONS DURING SYSTEMIC INFLAMMATION -- ABSTRACT -- INTRODUCTION -- ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) -- RENAL FIBROSIS -- HEART FIBROSIS -- GASTROINTESTINAL DYSFUNCTIONS -- MEDICAL APPLICATION OF TYPE I COLLAGENIN SYSTEMIC INFLAMMATION -- REFERENCES -- Chapter VI: COLLAGEN SCAFFOLDS: TISSUE ENGINEERING AND REPAIR -- ABSTRACT -- TISSUE ENGINEERING AND CONNECTIVE TISSUE REPAIR -- SCAFFOLDS FOR TISSUE ENGINEERING -- COLLAGEN-BASED SCAFFOLDS FOR ORAL-MAXILLOFACIAL,BONE, CARTILAGE, SKIN, AND VASCULAR TISSUE ENGINEERING -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter VII: BIOMEDICAL IMPLICATIONS OF TYPE I COLLAGEN: A MARINE PERSPECTIVE -- ABSTRACT -- INTRODUCTION -- STRUCTURAL AND FUNCTIONAL ASPECTS OF TYPE I COLLAGEN -- BIOMEDICAL APPLICATIONS OF TYPE I COLLAGEN -- MARINE DERIVED TYPE I COLLAGEN AND ITS BIOMEDICAL SIGNIFICANCE -- CONCLUSION -- REFERENCES -- Chapter VIII: ROLE OF EXTRACELLULAR MATRIXIN THE WOUND REPAIR PROCESS -- ABSTRACT -- THE EXTRACELLULAR MATRIX -- CELL-MATRIX INTERACTIONS -- ADVANCED WOUND HEALING THERAPIES -- CONCLUSIONS AND PERSPECTIVES -- REFERENCES -- INDEX.