ESTROGENS: BIOCHEMISTRY, THERAPEUTIC USES AND PHYSIOLOGICAL EFFECTS -- ESTROGENS: BIOCHEMISTRY, THERAPEUTIC USES AND PHYSIOLOGICAL EFFECTS -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter 1: ESTROGENS AS MEDIATORS OF OBESITY-INDUCED INFLAMMATION -- ABSTRACT -- ABBREVIATIONS -- ADIPOSE TISSUE-RELATED INFLAMMATION -- ESTROGEN SIGNALING -- ESTROGEN TURNOVER IN THE ADIPOSE TISSUE -- MODELS OF ESTROGEN INSUFFICIENCY -- ESTROGENS AND ADIPOSE TISSUE MASS, DISTRIBUTION AND CELLULARITY -- ESTROGENS AND AT INFLAMMATION -- XENOESTROGENS AND OBESITY-ASSOCIATED COMPLICATIONS -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 2: EFFECTS OF ESTROGEN USE, FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON COGNITIVE TESTS DEMANDING ATTENTION IN POSTMENOPAUSAL WOMEN -- INTRODUCTION -- METHOD -- Sustained Attention -- Attention Span -- Word Repetition Span -- RESULTS -- CONCLUSION -- AUTHOR CONTRIBUTIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3: THE ROLE OF ESTROGENS IN OSTEOARTHRITIS AND INFLAMMATION -- ABSTRACT -- INTRODUCTION -- ESTROGEN RECEPTORS STRUCTURE AND CHARACTERISTICS -- ESTROGEN ON INFLAMMATION -- ESTROGEN AND AUTOIMMUNE DISEASES: RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS -- ESTROGEN AND OSTEOARTHRITIS -- CONCLUSION -- COMPETING INTERESTS -- REFERENCES -- Chapter 4: ESTROGEN IN REGULATING THE GENDER DISPARITY OF HEPATOCELLULAR CARCINOMA -- ABSTRACT -- INTRODUCTION -- HCC OCCURS PREFERENTIALLY IN MALES,WITH THE SEX DIFFERENCE STARTING FROM CHRONIC HEPATITIS -- THE INVOLVEMENT OF ANDROGEN AXIS IN PROMOTING MALE HCC -- THE INVOLVEMENT OF ESTROGEN AXIS IN PROTECTING FEMALE HCC: EPIDEMIOLOGICAL EVIDENCE AND ANIMAL STUDIES -- WILD TYPE AND VARIANT ESTROGEN RECEPTORSIN NORMAL AND HCC LIVER TISSUES -- MOLECULAR MECHANISMS FOR THE PROTECTIVE ROLE OF ESTROGEN AXIS IN FEMALE HCC.

THE MECHANISMS OF ESTROGEN AXIS IN PREVENTING HEPATIC FIBROSIS AND STEATOSIS -- THE REGULATORY MECHANISMS FOR THE DOWN-REGULATION OF ERa IN FEMALE HCC -- THE INTERACTION BETWEEN THE HEPATITISVIRUS B AND ESTROGEN PATHWAY -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 5: POST-TRANSCRIPTIONAL EFFECTS OF ESTROGENS ON GENE EXPRESSION: MESSENGER RNA STABILITYAND TRANSLATION REGULATEDBY MICRORNAS AND OTHER FACTORS -- ABSTRACT -- INTRODUCTION -- ESTROGENS STABILIZE AND DESTABILIZESPECIFIC MRNAS -- ESTROGENS AFFECT MRNA TRANSLATION -- ESTROGEN ACTIONS AND MICRORNAS -- MicroRNAs - Biogenesis and Regulation of Gene Expression -- Estrogens Regulate Expression of MicroRNA Genes in Responsive Tissues during Normal Physiology and Disease -- MicroRNAs Regulate ER Gene Expression and Estrogen Actions -- FUTURE THERAPEUTIC APPROACHES TO REGULATINGPOST-TRANSCRIPTIONAL ESTROGEN ACTIONS -- CONCLUSION -- REFERENCES -- INDEX.