DIABETES MELLITUS RESEARCH ADVANCES -- DIABETES MELLITUS RESEARCH ADVANCES -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter 1: The Metabolic Syndrome: Genetic Effects in Endocrine Pathways -- Abstract -- 2. The Metabolic Syndrome: Concept, Definition, Effect and Prevalence -- 3. Pathophysiology of the Metabolic Syndrome -- 4. Causes of the Metabolic Syndrome: Genetics and Environment -- 5. Genetic Analysis of the Metabolic Syndrome -- 6. Genetic Variants in Endocrine Pathways Influencing Metabolic Syndrome -- 7. Gender Differences in Genetic Factors Influencing Metabolic Syndrome Risk -- 8. Interaction among Elements Influencing Metabolic Syndrome Risk -- 9. Network of Endocrine Setpoints as a Combined Contributor to Metabolic Syndrome Risk -- References -- Chapter 2: Reactive Oxygen Species and K+Channel Function in Diabetes and Insulin Resistance -- Abstract -- Introduction -- Physiological Importance and Basic Structure of K+ Channels -- Impaired Vasomotor Function in Diabetes and Insulin Resistance -- Hyperglycemia, Oxidative Stress and Sources for Generating Reactive Oxygen Species -- Activation of Diacylglycerol-Protein Kinase C Pathway -- Upregulation of NADPH Oxidase -- Mitochondrial Generation of ROS -- Hyperglycemia, Reactive Oxygen Species and K+ Channel Function -- Insulin Resistance and Vascular Disease -- Insulin Resistance and Vascular Reactivity -- Insulin Resistance and Potassium Channel Function -- Reactive Oxygen Species and Potassium Channel Function in Insulin Resistance -- Summary and Conclusions -- References -- Chapter 3: The Etiology of Obesity-Induced Insulin Resistance -- Abstract -- A. Introduction -- B. Brief Overview of Energy Homeostasis -- C. Insulin Action -- D. Insulin-Stimulated Signal Transduction -- E. Insulin Resistance and the Metabolic Syndrome.

F. The Link between Obesity and Insulin Resistance -- G. Perspective on Insulin Resistance and Treatment -- H. Selected References -- Chapter 4: Racial/Ethnic Disparities in Hypertension and Diabetes Ascribed to Differences in Obesity rate -- Abstract -- Introduction -- Methodologic Issues Associated with Studying Obesity and Racial/Ethnic Variations in Diseases -- Objective of Study -- Methods -- Results -- Discussion -- Public Health Implications of Findings -- Conclusion -- References -- Chapter 5: Chosen Life Aspects of Diabetic Patients -- Abstract -- Diabetic Patient on a Journey -- Access to Education and Employment for Diabetic Patient -- References -- Chapter 6: CNS Amyloidosis and Diabetes Mellitus: Vicious Circles of Misfolding -- Abstract -- Conclusion -- References -- Chapter 7: Erythrocyte Transplasma Membrane Electron Transport, Oxidative Stress, Body Mass and Lifestyle in Healthy and in Type 1 Diabetic Families -- Abstract -- Abbreviations -- Degenerative Diseases and Redox Cycling -- Transplasma Membrane Electron Transport Systems -- Electron Transfer across the Red Cell Membrane -- Diet, Lifestyle and Cell Antioxidant Capacity -- Our Previous Observations -- Objectives of the Study -- Conclusion -- Acknowledgments -- References -- Chapter 8: Impact of Oxidative Stresson Diabetes Mellitus and Inflammatory Bowel Diseases -- Abstract -- 2. Introduction -- 3. DNA Oxidative Damage and DNA Repair -- 4. Oxidative Stress and Pathophysiology of Diabetes Mellitus and Inflammatory Bowel Diseases -- 5. Our Study Examining Oxidative Stress, DNA Damage and DNA Repair in Patients with Diabetes Mellitus and Crohn Disease -- Conclusion -- Acknowledgments -- References -- Chapter 9: Stem Cell Therapy for Type 1 Diabetes Mellitus -- Abstract -- 1. Introduction -- 2. Functional Properties of Replacement β-Cells -- 3. Sources of Replacement β-Cells.

4. Obstacles to Generating β-Cells from Stem Cells -- 5. Conclusions -- Acknowledgments -- References -- Chapter 10: Explaining Type 2 Diabetes in Mexico: Patients' and Physicians' Perspectives -- Abstract -- Introduction -- Research Setting -- Methods -- Results -- Discussion -- References -- Index.