NEUROBLASTOMA RESEARCH TRENDS -- NEUROBLASTOMA RESEARCH TRENDS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter I: Cancer Stem Cell in Neuroblastoma: Diagnostic and Therapeutic Implications -- Abstract -- Introduction -- Heterogeneity in Neuroblastoma -- Cancer Stem Cell Theory -- Tumorigenesis of NB and Cancer Stem Cells -- Attempts to Isolate Cancer Stem Cells from NB -- Resistance of Cancer Stem Cells to Current Therapies -- Therapeutic Implications of Cancer Stem Cells: New Strategies for Eradicating Cancer Stem Cells -- Diagnostic Implications of CSCs in NB -- Oncogenic Implications of CSCs in NB: Development and Cancer -- Future Directions: Cancer Stem Cells and Stem Cell Niche -- References -- Chapter II: Perspectives of Proteomics Investigations of Neuroblastoma Chemoresistance -- Abstract -- Introduction -- Distinct Cell Type of Neuroblastoma -- Cancer Chemoresistance -- Cell Line Variants as in Vitro Model -- Human Neuroblastoma Characterization by Proteomic Approach -- Drug Response Investigations -- Conclusions -- References -- Chapter III: Down Syndrome's Protection Against Neuroblastoma: The Stromal and Neural Overmaturation Tracks -- Abstract -- Introduction -- Neuroblastoma Occurs Exceptionally in Children with DS -- Analysis of the Cases of Neuroblastic Tumors Reported in Infants and Children with DS -- Aspects of Adrenal Medulla in DS -- Genes on Chromosome 21 which could Protect Against Neural Cancer and Particularly Neuroblastoma -- Personal data: 1. S100 B inHibits the Growth of Neuroblastoma Cell Lines in Vitro and in Vivo -- Personal Data: 2. PCP4 Induces Earlier Neuroblastoma Differentiation -- Personal Data: 3 Trisomic 21 Fibroblast Extra Cellular Matrix Inhibits the Growth of Neuroblastoma Cell Lines -- A Protective Effect of Neural Cell Differentiation and Extra Cellular Medium?.

Conclusion -- Acknowledgments -- References -- Chapter IV: The p73 Target Genes in Human Malignant Neuroblasts are Related to Neuronal Development and Sympathetic Differentiation -- Abstract -- Abbreviations -- 1. Introduction -- 2. Identification and Classification of p73 -Target Genes -- 3. Analysis of Genes Induced by Adenoviral TAp73 or Np73 Expression in NB Cells -- 4. p73 Expression is Strongly Induced during Human NB Differentiation by Retinoic Acid -- 5. Conclusion -- Reference List -- Chapter V: The Relationships are between the Neuroblastome and Caspases 3, 8,9 -- Reference -- Chapter VI: Genome and Proteome in Neuroblastoma -- Introduction Genome in Neuroblastoma -- From Genome to Proteome -- Gene and Protein Microarray Analysis -- Proteomic Markers in Neuroblastoma -- Conclusion -- References -- Index.