Contents -- Preface -- Acknowledgments -- 1 INTRODUCTION -- Book subject matter -- Brain growth and development -- Investigative studies -- History of cerebral palsy -- Embryonic and fetal age -- National Collaborative Perinatal Project -- Section 1 -- 2 BRAIN GROWTH -- Introduction -- Intrauterine growth periods -- Growth functions -- Historic introduction to growth studies -- Allometric relationships of brain weight to body parameters -- Differential growth of brain regions -- Variations in weight of 'normal' organs at various ages -- Sex dimorphism -- Developing brain vulnerability -- Cellularity and total cell number -- Prenatal brain growth model -- Postnatal growth model -- Conclusions -- 3 FETAL VENTRICULAR SIZE, SURFACES, ANDAPPENDAGES -- Introduction: the embryonic development of ventricles -- Developmental changes in ventricular epithelia -- Relative ventricular sizes throughout gestation -- Dorsal mesodiencephalic junction: pineal, subcommissural organ, andmesocoelic recess -- Discussion -- Conclusion -- 4 GERMINAL TISSUE (S UBVENTRICULARZONE) -- Germinal matrix lining all ventricles -- Growth and loss of lateral ventricle germinal tissue -- Other embryonic ventricles -- Sonographic and fetal magnetic resonance images of normal germinal matrix -- Conclusion -- 5 SURFACE CONFIGURATION-GYRALPATTERN DEVELOPMENT -- Introduction -- Cortical surface area development: isocortex and allocortex -- Timing of gyration: changing gyral patterns related to gestational age -- Sulcal fundi, roots, pits, and annectant gyri -- Gyri, cortical thickness, neuronal maxima, and synapses -- Effects of preterm birth on gyral development -- Conclusion -- 6 MYELINATED TRACTS: GROWTH PATTERNS -- Introduction -- Materials and methods -- Sequence of myelination -- White matter hypoplasia -- Conclusion.

7 DEVELOPING BRAIN IMAGING ANDMagnetic resonance SPECTROSCOPY -- Introduction -- Prescanning evaluations -- Cranial ultrasonography or neurosonography -- Computed tomography -- Magnetic resonance imaging -- Magnetic resonance spectroscopy -- Basic principles of magnetic resonance -- Material -- Data presentation -- Normative developmental curves -- Regional variations -- Conclusions -- 8 ANGIOGENESIS -- Introduction -- Embryonic, fetal, and early childhood angiogenesis -- Blood-brain barrier development -- Conclusion -- Section 2 -- 9 DEVELOPMENTAL HUMAN FETALREACTIONS: AVOID, SQUINT, SCOWL,SNEER, AND PUCKER -- Introduction -- Background -- Results -- Neuroimaging -- Conclusion -- 10 BLAKE'S POUCH AND RETROCEREBELLARCYSTS: POSTERIOR FOSSA CYSTS -- Normal posterior fossa development and anatomy -- Leptomeningeal development -- Fourth ventricular roof development -- Cisterna magna -- Posterior fossa cysts: general -- Fibrous arachnoidal cysts -- Arachnoidal duplications: Arachnoidal cysts proper -- Blake's pouch and the opening of foramen of magendie -- Lateral recess cysts -- Dandy-Walker cysts -- 'Mega' cisterna magna -- Conclusion -- 11 Developmental Central NervousSystem Aberration -- Introduction -- Changes in brain components -- Changes in response to insults during specific developmental periods -- Other histologic changes in fetal brain -- Pathologic process locations -- Summary and conclusions -- 12 Cerebral White Matter Abnormalities -- Introduction -- Diffuse white matter hypertrophic astrocytes -- Amphophilic globules -- Acutely damaged glial cells -- Focal necroses -- Role of clustering in understanding relationships of various white matterhistologic features -- Perinatal telencephalic leukoencephalopathies and their risk factors -- Etiologic relationships among the five perinatal telencephalic leukoencephalopathies.

Ultrasonographic white matter abnormalities and clinical associations -- Summary -- Conclusion -- 13 Late Fetal and Perinatal BrainVascular Abnormalities andNecroses -- Overview -- Arterial -- Venous thrombotic occlusions -- Necroses of unknown origin -- Vascular organizational abnormalities -- Late cerebral consequences -- Transneuronal atrophy -- Neonatal extracorporeal membrane oxygenation complications -- Conclusions -- 14 FETAL AND NEONATAL INTRACRANIALHEMORRHAGE -- Introduction -- Changes in cranial configuration during birth resulting in intracranial hemorrhage -- Paradural hematoma -- Intracerebral parenchymal hemorrhage -- Cerebellar parenchymal hemorrhage -- Germinal matrix hemorrhage -- Intraventricular hemorrhage -- Conclusion -- 15 VENTRICULOMEGALY, LARGEHEAD, MEGALENCEPHALY, ANDHYDROCEPHALUS -- Introduction -- Ventriculomegaly secondary to white matter or neuronal loss with normalor small head size -- Large head -- Hydrocephalus -- Change from a plastic head to a rigid skull during growth -- Hydrocephalus: antecedents -- Other common antecedents of hydrocephalus -- The anatomic results of hydrocephalus -- Conclusions -- 16 DEVELOPING BRAIN REACTIONS DURINGCHRONIC CHILDHOOD DISEASE -- Introduction -- Gracile and cuneate nuclear neuroaxonal spheroids -- Failure of neuromelanin deposition in substantia nigra neurons duringearly-onset chronic childhood illness -- Accumulation of lipofuscin in pallidal glial cells during early-onset chronicchildhood illness -- Conclusion -- 17 CONCLUDING REMARKS -- Index -- Colour plate.