Front Matter -- List of Report Reviewers -- Preface -- Contents -- Executive Summary -- 1 Introduction -- 2 Overview of HLW Challenges at DOE Sites -- 3 Characterization -- 4 Retrieval and Pretreatment -- 5 Immobilization -- 6 Tank Closure and Other Long-Term Issues -- 7 EMSP Research Portfolio: Technological Risk and Desired Attributes -- 8 Summary -- References -- Appendix A Interim Report -- Appendix B Analysis of the EMSP Research Portfolio -- Appendix C Spent Nuclear Fuel Issues -- Appendix D EMSP Overview and HLW Research Program -- Appendix E Biographical Sketches of Committee Members -- Appendix F List of Presentations -- Appendix G -- Appendix H List of Acronyms.