DOGS -- Copyright -- CONTRIBUTORS -- Preface -- Contents -- 1 Introduction -- REFERENCES -- 2 Criteria for Selecting Experimental Animals -- GENETIC FACTORS -- BIOLOGIC FACTORS -- BEHAVIORAL FACTORS -- HAZARDS -- REFERENCES -- 3 Husbandry -- HOUSING -- Facilities -- Indoor Facilities -- Sheltered Housing Facilities -- Outdoor Facilities -- Environment and Environmental Control -- Temperature and Humidity -- Ventilation -- Power and Lighting -- Noise Control -- Chemicals and Toxic Substances -- Primary Enclosures -- Space Recommendations -- EXERCISE AND ENVIRONMENTAL ENRICHMENT -- FOOD -- Selecting Optimal Rations -- Feeding -- Contaminants -- WATER -- BEDDING AND RESTING APPARATUSES -- SANITATION -- IDENTIFICATION AND RECORDS -- Identification -- Record-Keeping -- Record-Keeping for Scientists and Animal-Care Staff -- Records Required by Federal Regulations -- EMERGENCY, WEEKEND, AND HOLIDAY CARE -- TRANSPORTATION -- Primary Enclosures -- Environmental Conditions -- Food and Water -- Other Requirements -- REFERENCES -- 4 Management of Breeding Colonies -- REPRODUCTION -- Reproductive Cycle of the Bitch -- Mating -- Natural Mating -- Artificial Insemination -- Pregnancy and Parturition -- NEONATAL CARE -- REPRODUCTIVE PROBLEMS -- False Estrus and Anestrus -- Delayed Parturition -- Pseudopregnancy -- SPECIAL NUTRITIONAL REQUIREMENTS -- Bitches -- Pups -- VACCINATION AND DEWORMING -- SOCIALIZATION OF PUPS -- Sensitive Period for Socialization -- Consequences of Inadequate Socialization -- Socialization Programs -- RECORD KEEPING -- REFERENCES -- 5 Veterinary Care -- PROCUREMENT -- General Considerations -- Sources -- Conditioning -- CONTROL OF INFECTIOUS DISEASES -- General Considerations -- Quarantine -- Research and Breeding Colonies -- Breeding Stock -- Pups -- Specific-Pathogen-Free Colonies -- CONTROL OF PARASITIC DISEASES -- Ectoparasites.

Endoparasites -- RECOGNITION AND ALLEVIATION OF PAIN AND DISTRESS -- Recognition of Distress Induced by Pain -- Alleviation of Pain -- Anesthetics -- Analgesics -- Recognition of Distress Not Induced by Pain -- Alleviation of Distress Not Induced by Pain -- SURGERY AND POSTSURGICAL CARE -- Presurgical Preparation -- Postsurgical Care -- EUTHANASIA -- Injection of Lethal Substances -- Inhalation Methods -- Physical Methods -- Human Considerations -- REFERENCES -- 6 Special Considerations -- PROTOCOL REVIEW -- RESTRAINT -- SPECIAL CARE FOR ANIMAL MODELS -- Aging -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Cardiovascular Diseases -- Congenital Heart Defects -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Induced Heart Defects -- Clinical Features -- Husbandry and Veterinary Care -- Hypertension -- Clinical Features -- Husbandry and Veterinary Care -- Ehlers-Danlos Syndrome -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Endocrinologic Diseases -- Clinical Features -- Husbandry and Veterinary Care -- Hematologic Disorders -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Immunologic Diseases -- Primary Immunodeficiency and Autoimmune Diseases -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Complement Deficiency -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Organ Transplantation -- Clinical Features -- Husbandry and Veterinary Care -- Lysosomal Storage Diseases -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Muscular Dystrophy -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Neurologic Disorders -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Ophthalmologic Disorders -- Clinical Features -- Husbandry and Veterinary Care.

Reproduction -- Orthopedic Disorders -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Radiation Injury -- Clinical Features -- Husbandry and Veterinary Care -- Reproduction -- Gene Therapy -- Hematopoietic Stem Cells -- Skin Keratinocytes -- Smooth Muscle Transplantation -- REFERENCES -- Appendix Cross Reference -- Index.