Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Copyright -- Preface -- Contents -- Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS -- REVIEW OF AEGL REPORTS -- REFERENCES -- Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances -- COMMITTEE MEMBERS -- OAK RIDGE NATIONAL LABORATORY STAFF -- NATIONAL ADVISORY COMMITTEE STAFF -- Appendix -- 1 Aniline1 Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Experimental Studies -- 2.2.2. Epidemiology Studies -- 2.2.3. Accidents -- 2.3. Developmental and Reproductive Effects -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Rats -- 3.1.2. Mice -- 3.2. Nonlethal Toxicity -- 3.2.1. Dogs -- 3.2.2. Rats -- 3.2.3. Mice -- 3.2.4 Guinea pigs -- 3.3. Developmental and Reproductive Effects -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Susceptible Subpopulations -- 4.4.2. Species Differences -- 4.4.3. Concentration-Exposure Duration Relationship -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLS.

8.1. AEGL Values and Toxicity Endpoints -- 8.2. Comparisons with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- 2 Arsine1 Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.1.1. Case Reports -- 2.2. Nonlethal Toxicity -- 2.2.1. Case Reports -- 2.2.2. Epidemiologic Studies -- 2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Nonhuman Primates -- 3.1.2. Dogs -- 3.1.3. Cats -- 3.1.4 Rats -- 3.1.5. Mice -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Rats -- 3.2.3. Mice -- 3.2.4. Hamsters -- 3.3. Developmental/Reproductive Toxicity -- 3.3.1. Rats -- 3.3.2. Mice -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Variability -- 4.4.2. Unique Physicochemical Properties -- 4.4.3. Concurrent Exposure Issues -- 5. DATA ANALYSIS AND PROPOSED AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS AND PROPOSED AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS AND PROPOSED AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS -- 8.1. AEGL Values and Toxicity Endpoints -- 8.2. Comparison with Other Standards and Criteria -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- 3 Monomethylhydrazine1 Acute Exposure Guideline Levels -- SUMMARY.

1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Acute Exposure Studies -- 2.2.2. Epidemiologic Studies -- 2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Nonhuman Primates -- 3.1.2. Dogs -- 3.1.3. Rats -- 3.1.4. Mice -- 3.1.5. Hamsters -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Dogs -- 3.2.3. Rats -- 3.2.4. Mice -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Variability -- 4.4.2. Unique Physicochemical Properties -- 4.4.3. Concurrent Exposure Issues -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Summary of Human Data Relevant to AEGL-2 -- 6.2. Summary of Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Summary of Human Data Relevant to AEGL-3 -- 7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS -- 8.1. AEGL Values and Toxicity Endpoints -- 8.2. Comparison with Other Standards and Criteria -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- 4 Dimethylhydrazine1 Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Acute Exposure Case Reports -- 2.2.2. Epidemiologic Studies -- 2.3. Developmental and Reproductive -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary.

3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1 Nonhuman Primates -- 3.1.2. Dogs -- 3.1.3. Rats -- 3.1.4. Mice -- 3.1.5. Hamsters -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Dogs -- 3.2.3. Rats -- 3.2.4. Mice -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Variability -- 4.4.2. Unique Physicochemical Properties -- 4.4.3. Concurrent Exposure Issues -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Summary of Human Data Relevant to AEGL-2 -- 6.2. Summary of Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. -- 7.1. Summary of Human Data Relevant to AEGL-3 -- 7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS -- 8.1. AEGL Values and Toxicity Endpoints -- 8.2. Comparison with Other Standards and Criteria -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendixes -- APPENDIX A DERIVATION OF AEGL VALUES -- Derivation of AEGL-1 -- Derivation of AEGL-2 -- Derivation of AEGL-3 -- APPENDIX B TIME SCALING CALCULATIONS FOR DIMETHYLHYDRAZINE AEGLS -- Dimethylhydrazine dog data from Weeks et al. 1963 -- Dimethylhydrazine rat data from Weeks et al. 1963 -- APPENDIX C CARCINOGENICITY ASSESSMENT OF DIMETHYLHYDRAZINE -- APPENDIX D DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR DIMETHYLHYDRAZINE (CAS NO. 57- ...