FrontMatter -- Contents -- Preface -- Introduction -- SIDEBAR:Why Use Animals? -- A Theory of Germs -- SIDEBAR:Overcoming Disease -- Vaccines -- SIDEBAR: Penguins! -- Understanding Epilepsy -- Surgical Advancements -- Cancer Therapies -- The Concept of Basic Research -- Safety Testing -- SIDEBAR: Cruelty Free -- Regulation of Animal Research -- Continuing Efforts to More Efficiently Use Laboratory Animals -- SIDEBAR: The 3 Rs in Action -- Conclusion -- Resources and Web Links -- BackMatter.