Cover -- Copyright -- Editors -- Preface -- Contents -- Section I - Neurotransmitters and Signal Transduction -- Neurotransmitters and Signal Transduction - Introduction -- 1 - Acetylcholine -- 2 - Serotonin -- 3 - Opioid Peptides and Their Receptors: Overview and Function in Pain Modulation -- 4 - Norepinephrine -- 5 - Regulation of G Protein-Coupled Receptors by Phosphorylation and Endocytosis -- 6 - The Diverse Roles of L-Glutamic Acid in Brain Signal Transduction -- 7 - Corticotropin-Releasing Factor: Physiology, Pharmacology, and Role in Central Nervous System Disorders -- 8 - Neurogenesis in Adult Brain -- 9 - Dopamine -- 10 - Astrocytes -- 11 - Synaptic Plasticity -- 12 - Gaba -- 13 - Substance P and Related Tachykinins -- 14 - Histamine -- 15 - Purinergic Neurotransmission -- 16 - Neurotrophic Factors and Intracellular Signal Transduction Pathways -- 17 - Regulation of Gene Expression -- Section II - Emerging Methods in Molecular Biology and Genetics -- Emerging Methods in Molecular Biology and Genetics - Introduction -- 18 - Using Human Genomics to Advance Neuropsychopharmacology -- 19 - Gene Targeting and Transgenic Technologies -- 20 - Gene Delivery into the Brain Using Viral Vectors -- 21 - Neuropsychopharmacology of Worms and Flies -- 22 - Beyond Binding: Molecular and Cell Biological Approaches to Studying G-Protein-Coupled Receptors -- 23 - Applying Functional Genomics to Neuropsychopharmacology -- Section III - Emerging Imaging Technologies and Their Application to Psychiatric Research -- Emerging Imaging Technologies and Their Application to Psychiatric Research -Introduction -- 24 - Automated 3D Analysis of Large Brain Mri Databases -- 25 - In Vivo Magnetic Resonance Spectroscopy Studies of the Glutamate and Gaba Neurotransmitter Cycles and Functional Neuroenergetics.

26 - The Spatial, Temporal, and Interpretive Limits of Functional MRI -- 27 - Diffusion Tensor Imaging -- 28 - Activation Paradigms in Affective and Cognitive Neuroscience: Probing the Neuronal Circuitry Underlying Mood and Anxiety Disorders -- 29 - Interactions Among Neuronal Systems Assessed with Functional Neuroimaging -- 30 - Measuring Brain Connectivity with Functional Imaging and Transcranial Magnetic Stimulation -- 31 - In Vivo Molecular Imaging: Ligand Development and Research Applications -- 32 - Event-Related Potentials and Magnetic Fields in the Human Brain -- Section IV - Drug Discovery and Evaluation -- Drug Discovery and Evaluation - Introduction -- 33 - The Role of Preclinical Models in the Development of Psychotropic Drugs -- 34 - Proof of Concept: Functional Models for Drug Development in Humans -- 35 - Ethical Aspects of Neuropsychiatric Research with Human Subjects -- 36 - Regulatory Issues -- 37 - Pharmacogenomics and Personalized Therapeutics in Psychiatry -- 38 - Pharmacokinetics, Pharmacodynamics, and Drug Disposition -- 39 - The Role of Pharmaceuticals in Mental Health Care Outcomes -- 40 - Issues in Clinical Trial Designs -- Section V - Disorders of Development -- Disorders of Development - Introduction -- 41 - The Molecular and Cellular Genetics of Autism -- 42 - Current and Emerging Therapeutics of Autistic Disorder and Related Pervasive Developmental Disorders -- 43 - Pathophysiology of Attention-Deficit/Hyperactivity Disorder -- 44 - Learning Disorders -- 45 - Psychosis in Childhood and Its Management -- 46 - Behavioral Phenotypes of Neurodevelopmental Disorders: Portals into the Developing Brain -- Section VI - Schizophrenia and related disorders -- Schizophrenia and related disorders - Introduction -- 47 - Schizophrenia: Course Over the Lifetime.

48 - Neurocognitive Functioning in Patients with Schizophrenia: An Overview -- 49 - Molecular and Population Genetics of Schizophrenia -- 50 - Animal Models Relevant to Schizophrenia Disorders -- 51 - Endophenotypes in Studies of the Genetics of Schizophrenia -- 52 - Neurochemistry of Schizophrenia: Glutamatergic Abnormalities -- 53 - Neural Circuitry Approaches to Understanding the Pathophysiology of Schizophrenia -- 54 - Functional Neuroimaging in Schizophrenia -- 55 - Structural Magnetic Resonance Imaging Studies in Schizophrenia -- 56 - Therapeutics of Schizophrenia -- 57 - The Economics of the Treatment of Schizophrenia -- 58 - Mechanism of Action of Atypical Antipsychotic Drugs -- 59 - Neurochemical and Neuropharmacological Imaging in Schizophrenia -- Section VII - Anxiety and stress disorder -- Anxiety and stress disorder - Introduction -- 60 - Anxiety and Stress Disorders: Course Over the Lifetime -- 61 - Genetic and other Vulnerability Factors for Anxiety and Stress Disorders -- 62 - Animal Models and Endophenotypes of Anxiety and Stress Disorders -- 63 - Neurobiological Basis of Anxiety Disorders -- 64 - Neural Circuitry of Anxiety and Stress Disorders -- 65 - Structural and Functional Imaging of Anxiety and Stress Disorders -- 66 - Current and Emerging Therapeutics of Anxiety and Stress Disorders -- 67 - The Economic Burden of Anxiety and Stress Disorders -- 68 - Mechanism of Action of Anxiolytics -- Section VIII - Affective disorders -- Affective disorders - Introduction -- 69 - The Course of Depression -- 70 - Risk Factors for Major Depression and Bipolar Disorder -- 71 - Bipolar Disorders: Review of Molecular Genetic Linkage Studies -- 72 - Molecular and Cellular Mechanisms in Depression -- 73 - Neurocircuitry of Mood Disorders -- 74 - Structural and Functional Imaging of Affective Disorders.

75 - Current and Emerging Therapeutics for Depression -- 76 - Electroconvulsive Therapy: Sixty Years of Progress and a Comparison with Transcranial Magnetic Stimulation and Vagal Nerve Stimulation -- 77 - Current and Emerging Treatments for Acute Mania and Long-Term Prophylaxis for Bipolar Disorder -- 78 - Cost-Effectiveness of the Newer Generation of Antidepressants -- 79 - Mechanism of Action of Antidepressants and Mood Stabilizers -- 80 - Hormonal and Gender Influences on mood Regulation -- 81 - Depression and the Medically Ill -- Section IX - Alzheimer and other dementias -- Alzheimer and other dementias - Introduction -- 82 - Alzheimer Disease: From Earliest Symptoms to End Stage -- 83 - Molecular Genetics of Alzheimer Disease -- 84 - Transgenic Mouse Models of Alzheimer Disease -- 85 - Cell and Molecular Neuropathology of Alzheimer Disease -- 86 - Structural and Functional Brain Imaging of Alzheimer Disease -- 87 - Current and Experimental Therapeutics of Alzheimer Disease -- 88 - Alzheimer Disease: Treatment of Noncognitive Behavioral Abnormalities -- 89 - Cost-Effectiveness of Therapeutics for Alzheimer Disease -- 90 - Neuropsychiatric Manifestations of Hiv-1 Infection and Aids -- 91 - Dementia with Lewy Bodies -- 92 - Molecular Pathophysiology of Stroke -- 93 - Current and Experimental Treatment of Stroke -- 94 - Tau Protein and Tauopathy -- Section X - Substance Use Disorders -- Substance Use Disorders - Introduction -- 95 - Neurocircuitry of Addiction -- 96 - Molecular and Cellular Biology of Addiction -- 97 - Recent Advances in Animal Models of Drug Addiction -- 98 - Vulnerability Factors for Alcoholism -- 99 - Molecular and Cellular Genetics of Alcohol Addiction -- 100 - Ethanol Abuse, Dependence, and Withdrawal: Neurobiology and Clinical Implications -- 101 - Alcoholism Pharmacotherapy.

102 - Pathophysiology and Treatment of Cocaine Dependence -- 103 - Application of Imaging Technologies in the Investigation of Drug Addiction -- 104 - Molecular and Cellular Neurobiology and Pathophysiology of Opiate Addiction -- 105 - Current and Experimental Therapeutics for the Treatment of Opioid Addiction -- 106 - Marijuana -- 107 - Therapeutics for Nicotine Addiction -- 108 - Psychedelic Drugs -- 109 - Epidemiology of Drug Dependence -- 110 - Neuroimaging of Cocaine Craving States: Cessation, Stimulant Administration, and Drug Cue Paradigms -- Section XI - Impulsive and Compulsive Disorders -- Impulsive and Compulsive Disorders - Introduction -- 111 The Course and Clinical Features of Obsessive-Compulsive Disorder -- 112 - The Pathophysiology and Genetics of Obsessive-Compulsive Disorder -- 113 - Imaging and Neurocircuitry of OCD -- 114 - Current and Experimental Therapeutics of Obsessive-Compulsive Disorder -- 115 - The Behavioral Neuroscience of Eating -- 116 - Psychopharmacology of Eating Disorders -- 117 - Tourette Syndrome and Related Tic Disorders -- 118 - Animal Models of Aggression -- 119 - Pathophysiology and Treatment of Aggression -- 120 - Pathologic Gambling and Impulse Control Disorders -- 121 - Compulsive and Impulsive Aspects of Self-Injurious Behavior -- Section XII - Movement Disorders and Proxysmal Disorders -- Movement Disorders and Proxysmal Disorders - Introduction -- 122 - Neurocircuitry of Parkinson's Disease -- 123 - Pathophysiology of Parkinson's Disease -- 124 - Current and Experimental Therapeutics of Parkinson's Disease -- 125 - Huntington Disease -- 126 - Clinical Course and Cellular Pathology of Tardive Dyskinesia -- 127 - Temporal Lobe Epilepsy: Renewed Emphasis on Extrahippocampal Areas -- Section XIII - Chronobiology and Sleep Disorders -- Chronobiology and Sleep Disorders - Introduction.

128 - Basic Mechanisms of Sleep: New Evidence on the Neuroanatomy andNeuromodulation of the NREM-REM Cycle.