Cover -- Title Page -- Copyright -- Contents -- Preface -- Cover Legend -- List of Contributors -- Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction -- Chapter 1 Metabolic Adaptation of Human Pathogenic Yersiniae -- Introduction -- Yersinia Life Cycles and Pathogenesis -- Carbon Metabolism and Links to Yersinia Pathogenesis -- Food Sources, Nutrient Sequestration, and Utilization -- Metabolic Pathways of Yersinia Crucial for Virulence -- Nutritional Virulence: Nutritional Adaptation Important for Pathogenesis -- Coordinated Control of Carbon Metabolism and Virulence -- Importance of Ions -- Importance of the Csr System -- Importance of CCR and the cAMP-Crp Complex -- Importance of Posttranscriptional Regulation Strategies -- Conclusions -- Acknowledgments -- References -- Chapter 2 Crosstalk between Metabolism and Virulence of Legionella pneumophila -- Introduction -- Key Metabolic Features of L. pneumophila -- Serine and Glucose Metabolism of L. pneumophila under In Vitro Conditions -- Metabolism of L. pneumophila under Intracellular Conditions -- Metabolic Adaptation during the Life Cycle of Intracellular L. pneumophila -- Metabolic Host Cell Responses Triggered by Intracellular L. pneumophila -- Conclusion -- References -- Chapter 3 Metabolism of Intracellular Salmonella enterica -- Introduction -- S. enterica-A Metabolic Generalist -- Metabolism of Glucose by S. enterica -- Connection to the TCA Cycle by Oxidative Decarboxylation of Pyruvate -- The Important Role of the TCA Cycle and Anaplerotic Reactions -- Metabolism of Intracellular S. enterica -- The Metabolism of S. enterica Compared to Other Important Intracellular and Gastrointestinal Pathogens -- Salmonella Induce Networks of Tubular Structures-Access to Host-Derived Nutrients? -- S. enterica Has a Bimodal Lifestyle in Epithelial Cells.

Salmonella Metabolism Limits Possibilities for New Antimicrobials -- Conclusions -- References -- Chapter 4 The Human Microbiome in Health and Disease -- Introduction -- Methods for Characterizing the Microbiota -- Diet and Geographical Factors -- Functional Gastrointestinal Disorders -- Manipulation of the Microbiota -- Conclusions -- Acknowledgments -- References -- Chapter 5 Mechanisms of Dysbiosis in the Inflamed Gut -- Introduction -- Dysbiosis during Inflammatory Diseases of the Gastrointestinal Tract -- Nutrient Acquisition by Commensal Bacteria in the Normal Gut -- Nutritional Mechanisms for Dysbiosis in the Inflamed Gut -- Inflammation-Driven Bloom of Enteric Pathogens in the Gut Lumen -- How Anaerobic Respiration Enhances Growth in the Inflamed Gut -- Conclusions -- References -- Chapter 6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice -- Introduction -- Adhesion and Germination -- Appressorium Formation -- Penetration -- Growth in Planta: The Biotrophic Growth Phase -- Growth in Planta: Necrotrophic Growth Phase -- Growth in Planta: Sporulation -- Life Outside of the Rice Plant -- Conclusion -- References -- Part Two New Inhibitors and Targets of Infectious Diseases -- Chapter 7 Outer Membrane Proteins as Potential Anti-infective Drug Targets in Mannheimia haemolytica -- Introduction -- Mannheimia haemolytica -- Pathogenesis of Pneumonic Pasteurellosis -- Virulence Factors of M. haemolytica -- Secreted Toxins and Extracellular Enzymes -- Leukotoxin -- Proteases -- Surface Proteins and Carbohydrates -- Capsule -- Lipopolysaccharide (LPS) -- Outer Membrane Proteins -- Antibiotic Use against M. haemolytica -- Antibiotic Resistance -- Resistance Mechanisms -- Discovery of New Antibacterial Agents -- The Importance of In Vivo Growth Conditions.

Potential Outer Membrane Targets for Novel Antibiotics against M. haemolytica -- Proteins involved in LPS biosynthesis -- Efflux Pumps -- Outer Membrane Biogenesis Proteins -- Proteins Involved in Adherence -- Proteins Involved in Iron Uptake and Other TonB-Dependent Proteins -- Conclusion -- References -- Chapter 8 Identification of Anti-infective Compounds Using Amoebae -- Introduction -- Anti-virulence Compounds as an Alternative to Antibiotics -- Amoebae as Model Host Systems in Compound Screening -- The Amoeba-Resistant Pathogens L. pneumophila and M. marinum -- Development of Novel Amoebae-Based Screening Systems -- Palmostatin M-A Novel Antibacterial Compound Specific for Legionella and Mycobacterium Species -- Conclusion -- Acknowledgments -- References -- Chapter 9 Stress Biology in Fungi and "Omic" Approaches as Suitable Tools for Analyzing Plant-Microbe Interactions -- Introduction -- Stress Signaling Pathways Are Important in Plant-Microbe Interactions -- High Osmolarity -- Reactive Oxygen Species (ROS) -- Plant Hormones (Phytoalexins) -- Technologies for Studying Signaling Pathways -- The Age of "Omics"-General Information -- Transcriptomics -- Transcriptomics in Use -- Proteomics -- Proteomics in Use -- Metabolomics -- Metabolomics in Use -- Conclusion -- References -- Chapter 10 Targeting Plasmids: New Ways to Plasmid Curing -- Introduction -- Research Approaches for Plasmid Curing -- Prerequisites for Clinical Use and Possible Application Methods -- Common Methods and Compounds in Use -- Approaches and Techniques to Identify Antiplasmid Effects/Compounds since 2000 -- Plasmid Incompatibility -- Toxin-Antitoxin Systems -- Inhibition of Conjugation -- Miscellaneous -- Conclusion -- References -- Chapter 11 Regulation of Secondary Metabolism in the Gray Mold Fungus Botrytis cinerea.

Botrytis cinerea, the Causal Agent of Gray Mold Disease -- Repertoire of Secondary Metabolites Produced by B. cinerea -- Expression of SM Genes during In Vitro and In Planta Conditions -- Pathway-Specific Regulation by Transcription Factors -- Concerted Regulation of Secondary Metabolism and Light-Dependent Development -- Regulation of Secondary Metabolism by Conserved Signal Transduction Pathways -- Role of the Chromatin Landscape in the Regulation of Secondary Metabolism? -- Concluding Remarks -- References -- Index -- EULA.