Part I: Current Challenges in Osteochondral Repair and Regeneration: Trauma vs Disease -- Advances for treatment of knee OC defects -- Emerging Concepts in Treating Cartilage, Osteochondral Defects and Osteoarthritis of the Knee and Ankle -- Osteoarthritis: Trauma Vs Disease -- Surgical Treatment Paradigms of Ankle Lateral Instability, Osteochondral Defects and Impingement -- Part II: Viscosupplementation -- Clinical management in early OA -- Hyaluronic Acid -- Semi-IPNs and IPNs Based Hydrogels -- Promising biomolecules -- Part III: Technological Advances in Osteochondral Tissue Engineering -- Nanoparticles-based systems for Osteochondral Tissue Engineering -- Stem cells for osteochondral regeneration -- PRP Therapy -- Enhancing biological and biomechanical fixation of osteochondral scaffold: a grand challenge -- Part IV: Osteochondral Tissue Engineering approaches -- Combination of polymeric supports and drug delivery systems for ostechondral regeneration -- Osteochondral Angiogenesis and Promoted Vascularization: New Therapeutic Target -- Models Of Disease -- Part V: In vitro models for Osteochondral Regeneration -- Tissue Engineering Strategies for Osteochondral Repair -- In vitro mimetic models for the bone-cartilage interface regeneration -- Bioreactors and microfluidics for osteochondral interface maturation -- Part VI: In vivo models for Osteochondral Regeneratio -- nSmall Animal Models -- Large animal models for Osteochondral Regeneration -- Index.