Therapeutic applications of quadruplex nucleic acids
Title:
Therapeutic applications of quadruplex nucleic acids
Author:
Neidle, Stephen.
Personal Author:
Edition:
1st ed.
Publication Information:
London ; Waltham, Mass. : Elsevier/Academic Press, 2012.
Physical Description:
xii, 196 p. : ill.
Contents:
Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures.
Abstract:
"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
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