Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
Title:
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
Author:
Ren, Shuxun
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (308 seconds)
Series:
Medicine
General Note:
Title from resource description page
Abstract:
The chronic administration of isoproterenol via an implanted osmotic pump has been used widely to mimic advanced heart failure in mice. Here, we describe detailed methods in surgical mini-pump implantation for the continuous isoproterenol administration over 3 weeks, as well as, echocardiographic assessment for the successful model creation.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/59646