Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Title:
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Author:
Fossey-Jouenne, Aurélie
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (554 seconds)
Series:
Chemistry
General Note:
Title from resource description page
Abstract:
Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/56926