Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Title:
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Author:
Ware, Kathryn E.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (702 seconds)
Series:
Developmental Biology
General Note:
Title from resource description page
Abstract:
We present here a cell culture method for inducing mesenchymal-epithelial transitions (MET) in sarcoma cells based on combined ectopic expression of microRNA-200 family members and grainyhead-like 2 (GRHL2). This method is suitable for better understanding the biological impact of phenotypic plasticity on cancer aggressiveness and treatments.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/55520