Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Title:
Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Author:
Misenko, Sarah M.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (474 seconds)
Series:
Immunology and Infection
General Note:
Title from resource description page
Abstract:
DNA repair pathways are essential for maintenance of genomic integrity and preventing mutation and cancer. The goal of this protocol is to quantify genomic instability by direct observation of chromosome aberrations in metaphase spreads from mouse B cells using fluorescent in situ hybridization (FISH) for telomeric DNA repeats.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/51806