Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
Title:
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
Author:
Kohman, Richie E.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (505 seconds)
Series:
Medicine
General Note:
Title from resource description page
Abstract:
A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/51452