Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Title:
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Author:
Miller, Jaimy
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (744 seconds)
Series:
Bioengineering
General Note:
Title from resource description page
Abstract:
We present a combination of Cryo-electron microscopy, lipid nanotechnology, and structure analysis applied to resolve the membrane-bound structure of two highly homologous FVIII forms: human and porcine. The methodology developed in our laboratory to helically organize the two functional recombinant FVIII forms on negatively charged lipid nanotubes (LNT) is described.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/51254