Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Title:
Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Author:
Castiel, Asher
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (953 seconds)
Series:
Medicine
General Note:
Title from resource description page
Abstract:
The cytotoxic activity of the phenanthridine PJ-34 in cancer cells undergoing mitosis was documented in real time by live confocal imaging. PJ-34 eradicated human breast cancer MDA-MB-231 cells harboring extra-centrosomes in mitosis. Unlike normal bi-focal mitosis, the extra-centrosomes were not clustered in the two spindle poles in the presence of PJ-34.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/50568