Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
Title:
Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
Author:
Lage, Hermann
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (476 seconds)
Series:
Biology
General Note:
Title from resource description page
Abstract:
For development of RNA interference (RNAi)-based therapies, a novel strategy was developed, transkingdom RNAi (tkRNAi). This technology uses non-pathogenic bacteria to produce and deliver therapeutic short hairpin RNA (shRNA) into target cells. Here, tkRNAi was successfully applied for reversal of classical ABCB1-mediated multidrug resistance (MDR) of cancer cells.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/2099