Intro -- Table of Contents -- Abstract -- List of papers -- Abbreviations -- Introduction and background -- 1. Corneal anatomy and physiology -- 2. Corneal transparency -- 3. Corneal response to injury and regeneration -- 4. Corneal diseases/conditions addressed in this thesis -- 5. Corneal imaging in the clinics -- 6. Corneal surgery -- 7. Alternatives to human donor corneas -- 8. Drug delivery to the anterior segment of the eye -- Aims of the thesis -- Materials and methods -- 1. Fabrication of bioengineered porcine collagen (BPC) -- 2. Biomaterial characterization before corneal implantation -- 3. Corneal laser surgeries -- 4. Postoperative clinical evaluation -- 5. Histopathological evaluation -- 6. Statistical analysis -- Results -- 1. Biomaterial characterization -- 2. Clinical evaluation following laser surgery -- 3. Histopathological evaluation -- Discussion -- Future perspectives -- Svensk sammanfattning -- Acknowledgements -- References -- Papers.