Intro -- Acknowledgements -- List of abbreviations -- Overview -- Terminology -- Background and purpose -- Preferred product characteristics -- PPCs for malaria vaccines to prevent infection -- PPCs for vaccines to reduce malaria morbidity and mortality -- PPCs for vaccines to reduce malaria transmission -- Clinical development considerations -- Vaccine development strategies and tools -- Malaria vaccine pipeline: status as of August 2022 -- Vaccination strategies for malaria control and elimination -- Special PPC considerations for seasonal vaccination -- Special PPC considerations for vaccination in emergency situations -- Special PPC considerations for malaria vaccines for P. vivax -- Clinical development pathways and evaluation tools -- WHO prequalification -- Programmatic suitability -- Access and affordability -- References -- Annex 1. Clinical development data standardization templates -- Annex 2. Potential comparator arms for superiority and non-inferiority trials.