Intro -- Foreword -- Acknowledgements -- Abbreviations and acronyms -- This year's report at a glance -- Avant-propos -- Le rapport de cette année en un clin d'oeil -- Prefacio -- El informe de este año de un vistazo -- 1 INTRODUCTION -- 2 OVERVIEW OF KEY EVENTS IN 2021-2022 -- 2.1 Global fund seventh replenishment -- 2.2 NEW WHO RECOMMENDATIONS -- 2.3 THE STRATEGY TO RESPOND TO ANTIMALARIAL DRUG RESISTANCE IN AFRICA -- 2.4 INITIATIVE TO STOP THE SPREAD OF AN. STEPHENSI -- 2.5 THE GLOBAL FRAMEWORK FOR THE RESPONSE TO MALARIA IN URBAN AREAS -- 2.6 ROLLOUT OF THE RTS,S/AS01 MALARIA VACCINE IN AREAS OF MODERATE TO HIGH MALARIA TRANSMISSION -- 2.7 HUMANITARIAN AND HEALTH EMERGENCIES -- 2.8 MALARIA SERVICE DISRUPTIONS DURING THE COVID-19 PANDEMIC -- 3 GLOBAL TRENDS IN THE BURDEN OF MALARIA -- 3.9 BURDEN OF MALARIA IN PREGNANCY -- 3.7 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO EUROPEAN REGION, 2000-2021 -- 3.6 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO REGION OF THE AMERICAS, 2000-2021 -- 3.5 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO WESTERN PACIFIC REGION, 2000-2021 -- 3.4 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO EASTERN MEDITERRANEAN REGION, 2000-2021 -- 3.3 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO SOUTH-EAST ASIA REGION, 2000-2021 -- 3.2 ESTIMATED MALARIA CASES AND DEATHS IN THE WHO AFRICAN REGION, 2000-2021 -- 3.1 GLOBAL ESTIMATES OF MALARIA CASES AND DEATHS, 2000-2021 -- 4 ELIMINATION AND THE HIGH BURDEN TO HIGH IMPACT APPROACH -- 4.1 Nearing elimination -- 4.2 MALARIA ELIMINATION CERTIFICATION -- 4.3 E-2025 INITIATIVE -- 4.4 THE GREATER MEKONG SUBREGION -- 4.5 PREVENTION OF RE-ESTABLISHMENT -- 4.6 THE HIGH BURDEN TO HIGH IMPACT APPROACH -- 5 SURVEILLANCE -- 5.1 COUNTRY IMPLEMENTATION OF DIGITAL MALARIA MODULES -- 5.2 MALARIA SURVEILLANCE ASSESSMENTS -- 6 INVESTMENTS IN MALARIA PROGRAMMES AND RESEARCH.

6.1 FUNDING TRENDS FOR MALARIA CONTROL AND ELIMINATION -- 6.2 INVESTMENTS IN MALARIA-RELATED R& -- D -- 7 DISTRIBUTION AND COVERAGE OF MALARIA PREVENTION, DIAGNOSIS AND TREATMENT -- 7.1 DISTRIBUTION AND COVERAGE OF ITNs -- 7.2 POPULATION PROTECTED WITH IRS -- 7.3 SCALE-UP OF SMC -- 7.4 COVERAGE OF IPTp USE BY DOSE -- 7.5 MALARIA DIAGNOSIS AND TREATMENT -- 8 GLOBAL PROGRESS TOWARDS THE GTS MILESTONES -- 8.1 GLOBAL PROGRESS -- 8.2 WHO AFRICAN REGION -- 8.3 WHO REGION OF THE AMERICAS -- 8.4 WHO EASTERN MEDITERRANEAN REGION -- 8.5 WHO SOUTH-EAST ASIA REGION -- 8.6 WHO WESTERN PACIFIC REGION -- 9 BIOLOGICAL AND OTHER THREATS TO MALARIA INTERVENTIONS -- 9.1 DELETIONS IN P. FALCIPARUM HISTIDINE-RICH PROTEIN 2 AND PROTEIN 3 GENESH -- 9.2 STATUS OF ANTIMALARIAL DRUG EFFICACY AND RESISTANCE (2015-2021) -- 9.3 VECTOR RESISTANCE TO INSECTICIDES -- 9.4 ANOPHELES STEPHENSI INVASION AND SPREAD -- 9.5 EFFECTIVENESS OF ITNS -- 9.7 BEYOND THE REACH OF ITNS: ADDRESSING RESIDUAL TRANSMISSION -- 10 MALARIA PREFERRED PRODUCTS AND R& -- D PIPELINE -- 10.1 PREFERRED PRODUCT CHARACTERISTICS AND TARGET PRODUCT PROFILES FOR NEW MALARIA INTERVENTIONS -- 10.2 MALARIA DIAGNOSTICS -- 10.3 MALARIA MEDICINES -- 10.4 MALARIA VECTOR CONTROL R& -- D PIPELINE -- 10.5 MALARIA VACCINES -- 11 KEY FINDINGS AND CONCLUSION -- 11.1 GLOBAL MALARIA RESPONSE AND TRENDS IN CASES AND DEATHS -- 11.2 RISKS TO PROGRESS AGAINST MALARIA -- 11.3 ENHANCING RESILIENCE -- 11.4 R& -- D PRODUCTS PIPELINE -- References -- Annexes -- Annex 1 - Data sources and methods -- References for Annex 1 -- ANNEX 2 - NUMBER OF ITNs DISTRIBUTED THROUGH CAMPAIGNS IN MALARIA ENDEMIC COUNTRIES, 2020-2022 -- ANNEX 3 -- ANNEX 3 - A. WHO AFRICAN REGION, a. WEST AFRICA -- ANNEX 3 - A. WHO AFRICAN REGION, b. CENTRAL AFRICA.

ANNEX 3 - A. WHO AFRICAN REGION, c. COUNTRIES WITH HIGH TRANSMISSION IN EAST AND SOUTHERN AFRICA -- ANNEX 3 - B. WHO REGION OF THE AMERICAS -- ANNEX 3 - C. WHO EASTERN MEDITERRANEAN REGION -- ANNEX 3 - D. WHO SOUTH-EAST ASIA REGION -- ANNEX 3 - E. WHO WESTERN PACIFIC REGION -- ANNEX 4 -- ANNEX 4 - A. POLICY ADOPTION, 2021 -- ANNEX 4 - B. ANTIMALARIAL DRUG POLICY, 2021 -- ANNEX 4 - C. FUNDING FOR MALARIA CONTROL, 2019-2021 -- ANNEX 4 - D. COMMODITIES DISTRIBUTION AND COVERAGE, 2019-2021 -- ANNEX 4 - Ea. HOUSEHOLD SURVEY RESULTS, 2017-2021, COMPILED BY STATCOMPILER -- ANNEX 4 - Eb. H OUSEHOLD SURVEY RESULTS, 2017-2021, COMPILED THROUGH WHO CALCULATIONS -- ANNEX 4 - F. POPULATION DENOMINATOR FOR CASE INCIDENCE AND MORTALITY RATE, AND ESTIMATED MALARIA CASES AND DEATHS, 2000-2021 -- ANNEX 4 - G. POPULATION DENOMINATOR FOR CASE INCIDENCE AND MORTALITY RATE, AND REPORTED MALARIA CASES BY PLACE OF CARE, 2021 -- ANNEX 4 - H. REPORTED MALARIA CASES BY METHOD OF CONFIRMATION, 2010-2021 -- ANNEX 4 - I. REPORTED MALARIA CASES BY SPECIES, 2010-2021 -- ANNEX 4 - J. REPORTED MALARIA DEATHS, 2010-2021 -- ANNEX 4 - K. METHODS FOR TABLES A-D-G-H-I-J.