Intro -- Acknowledgements -- Abbreviations -- 1 Introduction -- 2 Objectives -- 3 Summary -- 4 Session 1: the Paediatric Data Hub: the concept, where are we today and where do we need to go? -- 4.1 The GAP-F 2022-2024 strategy and role of the Paediatric Data Hub -- 4.2 Background and evolution of the Paediatric Data Hub -- 5 Session 2: Contributing to the safety and effectiveness question: methodological aspects to be considered -- 5.1 Using real-world data to supplement clinical trials -- 5.2 Capturing and creating data sets fit for purpose: infrastructure, intercommunicability, frameworks and capacity strengthening -- 6 Session 3: Real-world data for safety and effectiveness: who is doing what already? -- 6.1 WHO mapping of digital monitoring and evaluation systems for HIV programmes -- 6.2 Health information exchange, Western Cape, South Africa -- 6.3 Uganda: Ministry of Health national systems for HIV among children and UP-ART cohort -- 6.4 Real-world data for safety and effectiveness: Malawi electronic medical records system opportunities -- 7 Session 4: Panel discussion: looking beyond HIV: strategic GAP-f disease areas -- 7.1 TB -- 7.2 Cancer -- 7.3 Malaria -- 8 Session 5: Operationalization and next steps -- 9 Next steps -- Annex 1. List of participants -- Annex 2. Agenda.