Intro -- Acknowledgements -- Acronyms and abbreviations -- Glossary -- Executive summary -- Summary of essential health and enabling recommendations -- Chapter 1 -- Introduction -- Key populations for HIV, viral hepatitis and STIs -- Structural barriers -- HIV, viral hepatitis and STIs in key populations: dynamics and syndemics -- Responding to HIV, viral hepatitis and STIs in key populations -- Scope of these guidelines -- Goals and objectives -- Audience -- Guidelines' principles -- How to use these guidelines -- Chapter 2 -- Methods -- Overview -- Contributors to the guidelines -- Competing interests -- Defining the scope of the guidelines -- Values and preferences of key population members -- Developing prioritized packages -- Plans for dissemination and updating -- Chapter 3 -- Critical enablers -- Introduction -- Key populations' experience, values and preferences related to structural barriers and critical enablers -- Essential interventions for impact: critical enablers -- Legal and policy barriers and enablers -- Stigma and discrimination -- Community empowerment -- Violence -- Chapter 4 -- The recommended package of interventions -- Introduction -- Recommended package -- Essential for impact: enabling interventions -- Essential for impact: health interventions -- Supportive interventions -- Chapter 5 -- Packages by key population -- Introduction -- Sex workers -- People who inject drugs -- Men who have sex with men -- Trans and gender diverse people -- People in prisons and other closed settings -- Chapter 6 -- Service delivery -- Background -- Community-led services, task-sharing and involvement of key population peers -- Virtual interventions -- Decentralization -- Integration -- Self-care -- Differentiated service delivery -- Chapter 7 -- Programme and service considerations for young key population groups -- Background.

Changes to the legal and policy environments -- Elements of successful programming for young key populations -- Chapter 8 -- Developing the response: the decision-making, planning and monitoring process -- Introduction -- Situational analysis -- Planning and implementing the response -- Monitoring and evaluating the responses -- Ongoing planning and development of the response -- Introduction -- Methodology -- Chapter 9 -- Additional information on the development of new recommendations -- Evidence and decision-making for new recommendations -- References.