Intro -- Contents -- Acknowledgements -- Abbreviations and acronyms -- Executive Summary -- The Guideline -- 01 / Purpose and scope -- 02 / Methods for guideline development -- 2.1 Contributors to the guideline -- 2.2 Identification of priority questions and critical outcomes -- 2.3 Identification and retrieval of evidence -- 2.4 Quality assessment and grading of evidence -- 2.6 Development of recommendations -- 2.7 Good practice statements -- 2.8 Consultation with stakeholders -- 2.9 Document preparation and peer review -- 03 / Results of the review -- 3.1 Guiding principles -- 04 / Background -- 4.1 Principal sources of exposure to lead -- 4.2 Routes of exposure to lead -- 4.3 Toxicokinetics -- 4.4 Toxicity of lead -- 4.5 Toxic effects in relation to blood lead concentrations -- 05 / Diagnosis of lead poisoning -- 06 / Recommendation on the blood lead concentration that should initiate clinical interventions -- 6.1 Introduction -- 6.2 Recommendations for all age groups -- 6.3 Values, equity, feasibility and acceptability of a 5 µg/dL threshold value -- 6.4 Considerations for implementation -- 07 / Recommendations for specific treatment interventions -- 7.1 Gastrointestinal decontamination after ingestion of a lead foreign body or other lead-containing material -- 7.2 Nutritional interventions in children and in pregnant and lactating women exposed to lead -- 7.3 Chelation therapy in individuals exposed to lead -- 08 / Integration and implementation of the recommendations in the management of lead poisoning -- 8.1 Taking a history to Identify the source(s) of exposure -- 8.2 Evaluation of the severity of exposure -- 8.3 Reduction and termination of exposure, including improving nutrition -- 8.4 Chelation therapy -- 8.5 Supportive measures -- 8.6 Follow-up -- 09 / Research gaps -- 9.1 Gastrointestinal decontamination.

9.2 Nutritional interventions -- 9.3 Chelation therapy -- 10 / Considerations for implementation of the guideline -- References -- Annex 1 Members of the WHO Steering Group -- Annex 2 Guideline Development Group -- Annex 3 -- Research questions and critical and important outcomes -- Annex 4 External reviewers -- Annex 5Flowcharts summarizing aspects of patient management.