MIRRs: Structure and Physiological Function -- T-Cell Receptor -- B-Cell Receptor -- Fc Receptors -- Natural Killer Cell Receptors -- Platelet Glycoprotein VI -- MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize -- Clustering Models -- Segregation Models -- Kinetic Proofreading Model -- Serial Triggering Model -- Conformational Model -- Permissive Geometry Model -- Signaling Chain Homooligomerization (SCHOOL) Model -- Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses -- Visualization of Protein Interactions in Living Cells -- MIRR Signaling and Therapy of Immune Disorders -- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences -- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides -- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer -- Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease -- MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines -- SCHOOL Model and New Targeting Strategies -- Immune Receptor Signaling, Aging and Autoimmunity -- Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment.