Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Stress Response and Molecular Chaperones -- Biology of the Heat Shock Response and Stress Conditioning -- Bacterial Stress Sensors -- Unfolded Protein Response: Contributions to Development and Disease -- Molecular Mechanisms of Stress Protein Expression -- Genetic Models of HSF Function -- HSF1 and HSP Gene Regulation -- Cellular Stress Proteins -- Small Heat Shock Proteins in Physiological and Stress-Related Processes -- Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy -- Molecular Chaperones and Protein Folding -- Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors -- Protein Disassembly by Hsp40-Hsp70 -- Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol -- Role of Molecular Chaperones in Cell Regulation -- FKBP Co-Chaperones in Steroid Receptor Complexes -- Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP -- Role of Cdc37 in Protein Kinase Folding -- Intracellular and Extracellular Stress Proteins in Human Disease -- Targeting Hsp90 in Cancer and Neurodegenerative Disease -- gp96 and Tumor Immunity -- Immunoregulatory Activities of Extracellular Stress Proteins -- Heat Shock Proteins and Neurodegenerative Diseases -- Heat Shock Proteins in the Progression of Cancer.