History of Arrhythmias -- Pacemaker Current and Automatic Rhythms: Toward a Molecular Understanding -- Proarrhythmia -- Cardiac Na+ Channels as Therapeutic Targets for Antiarrhythmic Agents -- Structural Determinants of Potassium Channel Blockade and Drug-Induced Arrhythmias -- Sodium Calcium Exchange as a Target for Antiarrhythmic Therapy -- A Role for Calcium/Calmodulin-Dependent Protein Kinase II in Cardiac Disease and Arrhythmia -- AKAPs as Antiarrhythmic Targets? -- ?-Blockers as Antiarrhythmic Agents -- Experimental Therapy of Genetic Arrhythmias: Disease-Specific Pharmacology -- Mutation-Specific Pharmacology of the Long QT Syndrome -- Therapy for the Brugada Syndrome -- Molecular Basis of Isolated Cardiac Conduction Disease -- hERG Trafficking and Pharmacological Rescue of LQTS-2 Mutant Channels.