This monograph discusses the development and application of mobile wearable nano-bio health monitoring systems for telemedicine. In such a system, nanomaterials-based biosensors are used to measure physiological signals, such as electrocardiogram (ECG), electroencephalogram (EEG), electromyogram (EMG), and electrooculogram (EOG). The obtained physiological signals are filtered, amplified and transmitted to a remote storage server, utilizing Smartphones as the base stations. Cloud computing resources are used for complex computations, such as feature extraction and automatic diagnosis. The information in the remote storage server can be instantly accessed by healthcare providers, and the medical advice can also be sent instantly to the patient through the wireless communication system.