FrontMatter -- Institute of Medicine Roundtable on Value & Science-Driven Health Care Charter and Vision Statement -- Reviewers -- Contents -- Acronyms and Abbreviations -- 1 Introduction and Overview -- 2 Continuous Learning and Improvement in Health Care -- 3 Continuously Learning Health Care: The Value Proposition -- 4 Integrating Clinical Research and Practice: Examples -- 5 Creating the Conditions for Sustainability -- 6 Addressing Issues of Regulatory Oversight -- 7 Governance That Accelerates Progress and Sustainability -- 8 Fostering the Well-Prepared Stakeholder Culture -- 9 Multiuse Infrastructure for Continuous Learning -- 10 Continuous Learning as an Executive Agenda Priority -- 11 Recurring Workshop Themes -- References -- Appendix A: Workshop Agendas -- Appendix B: Biographical Sketches of Workshop Speakers -- Appendix C: Workshop Attendees.