Molecular Interactions and Activity in Proteins -- Contents -- Intramolecular interactions, enzyme activity and models -- Discussion -- Solvents, interfaces and protein structure -- Discussion -- The chemical properties of out-of-equilibrium states of proteins and the role of these states in protein function -- Flexibility and rigidity in protein crystals -- Discussion -- Coenzyme-induced conformational changes and substrate binding in liver alcohol dehydrogenase -- Discussion -- The consequences of nucleotide binding to liver alcohol dehydrogenase -- Discussion -- Origins of specificity in the binding of small molecules to dihydrofolate reductase -- Discussion -- Polypeptide hormone-receptor interactions: the structure and receptor binding of insulin and glucagon -- Discussion -- Perturbations of model protein systems as a basis for the central and peripheral mechanisms of general anaesthesia -- Discussion -- Physical and chemical properties of lysozyme -- Discussion -- The free radical in ribonucleotide reductase from E. coli -- Discussion -- Dynamics of local conformation and enzyme function -- Discussion -- To stabilize a transition state -- Discussion -- Stereochemical studies on enzymic C-methylations -- Discussion -- General Discussion -- Reactions in supercooled water -- Studies of active sites of metalloenzymes using perturbed angular correlation of γ-radiation -- Concluding remarks -- Index of contributors -- Subject index.