Protein Kinase C-Theta (PKC?): New Perspectives on Its Functions in T Cell Biology -- Travel Informations on the TEC Kinases during Lymphocyte Activation -- Inducible T Cell Tyrosine Kinase (ITK): Structural Requirements and Actin Polymerization -- Differential Requirements of PI3K Subunits for BCR or BCR/CD19-Induced ERK Activation -- Protein Tyrosine Phosphatases in Human Disease -- The T Cell-Specific Adapter Protein Functions as a Regulator of Peripheral but not Central Immunological Tolerance -- Proximal Signals Controlling B-Cell Antigen Receptor (BCR) Mediated NF-?B Activation -- The Adapter 3BP2: How It Plugs into Leukocyte Signaling -- CTLA-4 Regulation of T Cell Function via RAP-1-Mediated Adhesion -- Protein Crosstalk in Lipid Rafts -- Role of Lipid Rafts in Activation-Induced Cell Death : The Fas Pathway in Aging -- T Cell Response in Aging: Influence of Cellular Cholesterol Modulation -- Lymphocyte Signaling and the Translatability of mRNA -- Protein Arginine Methylation: A New Frontier in T Cell Signal Transduction -- Immune Regulation by Ubiquitin Conjugation -- CTIB (C-Terminus Protein of I?B-?: A Novel Factor Required for Acidic Adaptation -- HIV May Deplete Most CD4 Lymphocytes by a Mechanism Involving Signaling through its Receptors on Non-Permissive Resting Lymphocytes -- Integrating Traditional and Postgenomic Approaches to Investigate Lymphocyte Development and Function -- Phosphoproteomic Analysis of Lymphocyte Signaling.