Hemostasis and Thrombosis -- CONTRIBUTING AUTHORS -- PREFACE -- FROM THE PREFACE TO THE FIRST EDITION -- ACKNOWLEDGMENTS -- CONTENTS -- PART I Introduction to the Field of Hemostasis and Thrombosis -- The Field of Hemostasis and Thrombosis: Selected Translational Achievements -- Molecular Evolution of the Vertebrate Blood Coagulation System -- Molecular and Clinical Genetics -- Coagulation Enzymology -- Cell Biology, Protein Processing, and Cell Signaling -- Overview of the Immune System -- Biostatistics and Epidemiology: The Basic Science of Clinical Research -- PART II Basic Principles of Hemostasis and Thrombosis -- SECTION A COAGULATION AND FIBRINOLYSIS -- Overview of Basic Coagulation and Fibrinolysis -- The Blood Coagulation Factors and Inhibitors: Their Primary Structure, Complementary DNAs, Genes, and Expression -- Genetics of Coagulation -- Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation -- Factor V and Factor VIII -- Structure and Function of von Willebrand Factor -- Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins -- Factor XI -- The Factor XII-Driven Plasma Contact System -- Fibrinogen Structure and Function -- Factor XIII -- Antithrombin and the Serpin Family -- Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways -- Plasminogen Activation and Regulation of Fibrinolysis -- Inhibitors of Fibrinolysis -- SECTION B PLATELET BIOLOGY -- Overview of Megakaryocyte and Platelet Biology -- Platelet Production: Cellular and Molecular Regulation -- Megakaryocyte Structure and Platelet Biogenesis -- Thrombopoietin -- Major Platelet Glycoproteins: Platelet Glycoprotein Ib-IX-V -- Major Platelet Glycoproteins: INTEGRIN αIIbβ3 (GPIIb-IIIa) -- Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity -- The Basis for Platelet Adhesion.

Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis -- Platelet Collagen Receptors -- Integrin αIIbβ3 and Platelet Aggregation -- Molecular Basis for Platelet Secretion -- Platelet Signal Transduction -- Platelet Prostanoid Metabolism -- The Role of Platelets in Blood Coagulation -- Blood-Borne Microparticles -- SECTION C VASCULAR BIOLOGY -- Overview of Vascular Biology -- Development of the Vasculature, Angiogenesis, and Lymphangiogenesis -- Rheology and Vessel Wall Stress -- Nitric Oxide: The Vascular Biology of Nitric Oxide and Nitric Oxide Synthases -- Blood Vessel Wall in Health and Disease -- Endothelial Cell Function -- Role of the Endothelium in Hemostasis -- Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway -- Heparin and Vascular Proteoglycans -- Endothelial Cell-Blood Cell Interactions -- Leukocyte Function and Contribution to Disease -- Laboratory Markers of Endothelial Cell Activation and Dysfunction -- PART III Disorders of Coagulation, Platelets, and Vessel Wall -- SECTION A BLEEDING DISORDERS OF COAGULATION AND FIBRINOLYSIS -- Overview of Inherited Hemorrhagic Disorders -- Differential Diagnosis of the Bleeding Patient -- Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia -- SECTION B ACQUIRED AND INHERITED PLATELET DISORDERS -- Overview of Acquired and Inherited Clinical Platelet Disorders -- Differential Diagnosis of Thrombocytopenia -- Immune Thrombocytopenia and Posttransfusion Purpura -- Drug-Induced Thrombocytopenia -- Inherited Thrombocytopenias -- Acquired Nonimmune Thrombocytopenia -- Inherited Disorders of Platelet Function -- Acquired Disorders of Platelet Function -- Laboratory Markers of Platelet Activation -- SECTION C PRIMARY DISORDERS OF BLOOD VESSELS -- Overview of Primary Disorders of Blood Vessels.

Disorders of Connective Tissue and Extracellular Matrix -- Hereditary Hemorrhagic Telangiectasia -- Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations -- Aneurysms (Large and Small Arteries) -- Intracranial Hemorrhage and Subarachnoid Hemorrhage -- Retinopathy -- SECTION D THERAPY OF BLEEDING DISORDERS -- Overview of Therapy of Bleeding Disorders -- Management of Acute Hemorrhage -- Therapy with Antifibrinolytic Agents -- Platelets, Plasma, and Specialized Coagulation Concentrate Therapies -- New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy -- PART IV: THROMBOTIC DISORDERS -- SECTION A VENOUS THROMBOTIC DISORDERS -- Overview of Venous Thromboembolism -- Thrombophilia Genetics -- Epidemiology and Risk Factors for Venous Thromboembolism -- Clinical Manifestations and Diagnosis of Venous Thromboembolism -- Venous Thrombosis in Unusual Sites -- Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension -- Prevention of Venous Thromboembolic Disease -- Treatment of Venous Thromboembolic Disease -- SECTION B ARTERIAL THROMBOTIC DISORDERS -- Overview of Arterial Thrombotic Disorders -- Pathophysiology of Atherothrombosis -- Acute Coronary Syndromes: Manifestations and Management -- Pathophysiology of Thromboembolic Stroke -- Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, or Cardiomyopathy -- Ischemic Stroke: Acute Thrombolytic Therapy, Antithrombotic Approaches, and General Management -- Medical and Surgical Treatment of Peripheral Arterial Disease -- Unusual Sites of Arterial Occlusion -- Pathogenesis and Treatment of Biomaterial-Associated Thrombosis -- SECTION C COMPLEX THROMBOTIC DISORDERS -- Overview of Complex Thrombohemorrhagic Disorders -- Consumptive Thrombohemorrhagic Disorders.

The Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndromes -- Vasculitides -- The Antiphospholipid Syndrome -- Myeloproliferative Neoplasms and Thrombohemorrhagic Complications -- Thrombotic and Hemorrhagic Complications Associated with Stem Cell Transplantation -- SECTION D THERAPEUTIC AGENTS -- Overview of Therapeutic Agents Used in Thrombotic Disorders -- Pharmacology and Mode of Action of Heparin and Glycosaminoglycans -- Vitamin K Antagonists: Biochemistry, Pharmacology, and Management -- Hemorrhagic Complications of Anticoagulation -- Heparin-Induced Thrombocytopenia -- Coumarin-Induced Skin Necrosis and Venous Limb Gangrene -- New Antithrombotic Drugs -- Antiplatelet Therapy -- Foundations of Thrombolytic Therapy -- Anticoagulant and Procoagulant Proteins in the Animal Kingdom -- Mechanical Devices and Embolectomy -- PART V Hemostatic and Thrombotic Disorders Associated with Systemic Conditions -- Overview of Special Clinical Groups -- Venous Thromboembolism during Pregnancy and with Hormonal Contraceptives -- Gestational Vascular Complications -- Maternal Hemostatic Disorders and Obstetric Hemorrhage -- Developmental Hemostasis -- Bleeding in Neonates and Children -- Venous and Arterial Thromboembolism in Children -- Thrombotic Complications of Sickle Cell Disease -- Thrombohemorrhagic Complications of Sepsis -- Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features -- Cancer-Related Thrombosis -- Hemostatic Challenges in Liver Disease -- Hemostatic Abnormalities in Renal Disease -- Multitrauma Derangements in Hemostasis and Thrombosis -- Blood Management in the Cardiovascular Surgical Patient -- Thrombohemorrhagic Events in the Elderly: Special Considerations -- INDEX.