Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
Title:
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
Author:
Allan, Kristina J.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (531 seconds)
Series:
Cancer Research
General Note:
Title from resource description page
Abstract:
Here we describe a protocol for employing high-throughput RNAi screening to uncover host targets that can be manipulated to enhance oncolytic virus therapy, specifically rhabodvirus and vaccinia virus therapy, but it can be readily adapted to other oncolytic virus platforms or for discovering host genes that modulate virus replication generally.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/56913