Cover image for Endocrine Manifestations of Systemic Autoimmune Diseases.
Endocrine Manifestations of Systemic Autoimmune Diseases.
Title:
Endocrine Manifestations of Systemic Autoimmune Diseases.
Author:
Asherson, Ronald.
ISBN:
9780080559322
Personal Author:
Physical Description:
1 online resource (821 pages)
Series:
Handbook of Systemic Autoimmune Diseases ; v.9

Handbook of Systemic Autoimmune Diseases
Contents:
Cover -- Table of contents -- Preface -- Chapter 1. Introduction -- 1.1 Statistics Defined -- 1.2 Types of Statistics -- 1.3 Levels of Discourse: Sample vs. Population -- 1.4 Levels of Discourse: Target vs. Sampled Population -- 1.5 Measurement Scales -- 1.6 Sampling and Sampling Errors -- 1.7 Exercises -- Chapter 2. Elementary Descriptive Statistical Techniques -- 2.1 Summarizing Sets of Data Measured on a Ratio or Interval Scale -- 2.2 Tabular Methods -- 2.3 Quantitative Summary Characteristics -- 2.4 Correlation between Variables X and Y -- 2.5 Rank Correlation between Variables X and Y -- 2.6 Exercises -- Chapter 3. Probability Theory -- 3.1 Mathematical Foundations: Sets, Set Relations, and Functions -- 3.2 The Random Experiment, Events, Sample Space, and the Random Variable -- 3.3 Axiomatic Development of Probability Theory -- 3.4 The Occurrence and Probability of an Event -- 3.5 General Addition Rule for Probabilities -- 3.6 Joint, Marginal, and Conditional Probability -- 3.7 Classification of Events -- 3.8 Sources of Probabilities -- 3.9 Bayes' Rule -- 3.10 Exercises -- Chapter 4. Random Variables and Probability Distributions -- 4.1 Random Variables -- 4.2 Discrete Probability Distributions -- 4.3 Continuous Probability Distributions -- 4.4 Mean and Variance of a Random Variable -- 4.5 Chebyshev's Theorem for Random Variables -- 4.6 Moments of a Random Variable -- 4.7 Quantiles of a Probability Distribution -- 4.8 Moment-Generating Function -- 4.9 Probability-Generating Function -- 4.10 Exercises -- Chapter 5. Bivariate Probability Distributions -- 5.1 Bivariate Random Variables -- 5.2 Discrete Bivariate Probability Distributions -- 5.3 Continuous Bivariate Probability Distributions -- 5.4 Expectations and Moments of Bivariate Probability Distributions -- 5.5 Chebyshev's Theorem for Bivariate Probability Distributions.

5.6 Joint Moment-Generating Function -- 5.7 Exercises -- Chapter 6. Discrete Parametric Probability Distributions -- 6.1 Introduction -- 6.2 Counting Rules -- 6.3 Discrete Uniform Distribution -- 6.4 The Bernoulli Distribution -- 6.5 The Binomial Distribution -- 6.6 The Multinomial Distribution -- 6.7 The Geometric Distribution -- 6.8 The Negative Binomial Distribution -- 6.9 The Poisson Distribution -- 6.10 The Hypergeometric Distribution -- 6.11 The Generalized Hypergeometric Distribution -- 6.12 Exercises -- Chapter 7. Continuous Parametric Probability Distributions -- 7.1 Introduction -- 7.2 The Uniform Distribution -- 7.3 The Normal Distribution -- 7.4 The Normal Approximation to Binomial Probabilities -- 7.5 The Normal Approximation to Poisson Probabilities -- 7.6 The Exponential Distribution -- 7.7 Gamma and Beta Functions -- 7.8 The Gamma Distribution -- 7.9 The Beta Distribution -- 7.10 Other Useful Continuous Distributions -- 7.11 Exercises -- Chapter 8. Sampling and the Sampling Distribution of a Statistic -- 8.1 The Purpose of Random Sampling -- 8.2 Sampling Scenarios -- 8.3 The Arithmetic of Random Sampling -- 8.4 The Sampling Distribution of a Statistic -- 8.5 The Sampling Distribution of the Mean -- 8.6 A Weak Law of Large Numbers -- 8.7 Convergence Concepts -- 8.8 A Central Limit Theorem -- 8.9 The Sampling Distribution of a Proportion -- 8.10 The Sampling Distribution of the Variance -- 8.11 A Note on Sample Moments -- 8.12 Exercises -- Chapter 9. The Chi-Square, Student's t, and Snedecor's F Distributions -- 9.1 Derived Continuous Parametric Distributions -- 9.2 The Chi-Square Distribution -- 9.3 The Sampling Distribution of the Variance When Sampling from a Normal Population -- 9.4 Student's t Distribution -- 9.5 Snedecor's F Distribution -- 9.6 Exercises -- Chapter 10. Point Estimation and Properties of Point Estimators.

10.1 Statistics as Point Estimators -- 10.2 Desirable Properties of Estimators as Statistical Properties -- 10.3 Small Sample Properties of Point Estimators -- 10.4 Large Sample Properties of Point Estimators -- 10.5 Techniques for Finding Good Point Estimators -- 10.6 Exercises -- Chapter 11. Interval Estimation and Confidence Interval Estimates -- 11.1 Interval Estimators -- 11.2 Central Confidence Intervals -- 11.3 The Pivotal Quantity Method -- 11.4 A Confidence Interval for µ Under Random Sampling from a Normal Population with Known Variance -- 11.5 A Confidence Interval for µ Under Random Sampling from a Normal Population with Unknown Variance -- 11.6 A Confidence Interval for s2 Under Random Sampling from a Normal Population with Unknown Mean -- 11.7 A Confidence Interval for p Under Random Sampling from a Binomial Population -- 11.8 Joint Estimation of a Family of Population Parameters -- 11.9 Confidence Intervals for the Difference of Means When Sampling from Two Independent Normal Populations -- 11.10 Confidence Intervals for the Difference of Means When Sampling from Two Dependent Populations: Paired Comparisons -- 11.11 Confidence Intervals for the Difference of Proportions When Sampling from Two Independent Binomial Populations -- 11.12 Confidence Interval for the Ratio of Two Variances When Sampling from Two Independent Normal Populations -- 11.13 Exercises -- Chapter 12. Tests of Parametric Statistical Hypotheses -- 12.1 Statistical Inference Revisited -- 12.2 Fundamental Concepts for Testing Statistical Hypotheses -- 12.3 What Is the Research Question? -- 12.4 Decision Outcomes -- 12.5 Devising a Test for a Statistical Hypothesis -- 12.6 The Classical Approach to Statistical Hypothesis Testing -- 12.7 Types of Tests or Critical Regions -- 12.8 The Essentials of Conducting a Hypothesis Test.

12.9 Hypothesis Test for µ Under Random Sampling from a Normal Population with Known Variance -- 12.10 Reporting Hypothesis Test Results -- 12.11 Determining the Probability of a Type II Error β -- 12.12 Hypothesis Tests for µ Under Random Sampling from a Normal Population with Unknown Variance -- 12.13 Hypothesis Tests for p Under Random Sampling from a Binomial Population -- 12.14 Hypothesis Tests for σ2 Under Random Sampling from a Normal Population -- 12.15 The Operating Characteristic and Power Functions of a Test -- 12.16 Determining the Best Test for a Statistical Hypothesis -- 12.17 Generalized Likelihood Ratio Tests -- 12.18 Hypothesis Tests for the Difference of Means When Sampling from Two Independent Normal Populations -- 12.19 Hypothesis Tests for the Difference of Means When Sampling from Two Dependent Populations: Paired Comparisons -- 12.20 Hypothesis Tests for the Difference of Proportions When Sampling from Two Independent Binomial Populations -- 12.21 Hypothesis Tests for the Difference of Variances When Sampling from Two Independent Normal Populations -- 12.22 Hypothesis Tests for Spearman's Rank Correlation Coefficient .S -- 12.23 Exercises -- Chapter 13. Nonparametric Statistical Techniques -- 13.1 Parametric vs. Nonparametric Methods -- 13.2 Tests for the Randomness of a Single Sample -- 13.3 Single-Sample Sign Test Under Random Sampling -- 13.4 Wilcoxon Signed Rank Test of a Median -- 13.5 Runs Test for Two Independent Samples -- 13.6 Mann-Whitney (Rank-Sum) Test for Two Independent Samples -- 13.7 The Sign Test When Sampling from Two Dependent Populations: Paired Comparisons -- 13.8 Wilcoxon Signed Rank Test When Sampling from Two Dependent Populations: Paired Comparisons -- 13.9 Exercises -- Chapter 14. Testing Goodness of Fit -- 14.1 Distributional Hypotheses.

14.2 The Multinomial Chi-Square Statistic: Complete Specification of H0 -- 14.3 The Multinomial Chi-Square Statistic: Incomplete Specification of H0 -- 14.4 The Kolmogorov-Smirnov Test for Goodness of Fit -- 14.5 The Lilliefors Goodness-of-Fit Test for Normality -- 14.6 The Shapiro-Wilk Goodness-of-Fit Test for Normality -- 14.7 The Kolmogorov-Smirnov Test for Goodness of Fit: Two Independent Samples -- 14.8 Assessing Normality via Sample Moments -- 14.9 Exercises -- Chapter 15. Testing Goodness of Fit: Contingency Tables -- 15.1 An Extension of the Multinomial Chi-Square Statistic -- 15.2 Testing Independence -- 15.3 Testing k Proportions -- 15.4 Testing for Homogeneity -- 15.5 Measuring Strength of Association in Contingency Tables -- 15.6 Testing Goodness of Fit with Nominal-Scale Data: Paired Samples -- 15.7 Exercises -- Chapter 16. Bivariate Linear Regression and Correlation -- 16.1 The Regression Model -- 16.2 The Strong Classical Linear Regression Model -- 16.3 Estimating the Slope and Intercept of the Population Regression Line -- 16.4 Mean, Variance, and Sampling Distribution of the Least Squares Estimators . β0 and . β1 -- 16.5 Precision of the Least Squares Estimators . β0, . β1: Confidence Intervals -- 16.6 Testing Hypotheses Concerning β0, β1 -- 16.7 The Precision of the Entire Least Squares Regression Equation: A Confidence Band -- 16.8 The Prediction of a Particular Value of Y Given X -- 16.9 Decomposition of the Sample Variation of Y -- 16.10 The Correlation Model -- 16.11 Estimating the Population Correlation Coefficient . -- 16.12 Inferences about the Population Correlation Coefficient . -- 16.13 Exercises -- Appendix A -- Solutions to Selected Exercises -- References and Suggested Reading -- Index.
Abstract:
This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. *The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy *The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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