Obesity and Diabetes -- Contents -- Foreword -- List of Contributors -- 1 Changing Epidemiology of Obesity - Implications for Diabetes -- Introduction -- Assessment of obesity in epidemiological studies -- Prevalence of obesity -- The epidemiological link between obesity and diabetes -- Factors modifying the relationship between obesity and diabetes -- Conclusions -- References -- 2 The Genetics of Human Obesity -- Introduction -- Why has the genetics of obesity been difficult to study? -- How much of obesity is genetic? -- Is there a major gene for obesity? -- How to identify obesity genes -- Summary and conclusions -- References -- 3 Lifestyle Determinants of Obesity -- The importance of energy balance -- Physical activity -- Energy intake -- Environmental impacts on lifestyle -- An integrated analysis -- Conclusions -- References -- 4 Pathogenesis of Obesity-Related Type 2 Diabetes -- Introduction -- Defining fat accumulation in terms of health risk -- Implications of obesity-associated diabetes -- Development of obesity-related type 2 diabetes -- Fat distribution -- Evaluating obesity-related hypotheses for progression of type 2 diabetes -- Ectopic fat storage: fat content in obesity -- Lipid metabolism in adipose tissue -- Effects of NEFA on hepatic insulin action -- Adipose-tissue derived factors -- Summary -- References -- 5 Obesity and Prevention of Type 2 Diabetes -- Obesity and the risk of type 2 diabetes -- Lifestyle intervention studies -- Other intervention studies -- Conclusions -- References -- 6 Diet and Food-based Therapies for Obesity in Diabetic Patients -- Introduction -- Type 2 diabetes -- Patterns of weight loss in diabetes -- Target setting -- Dietary and lifestyle alterations -- Dietary nutrient composition in type 2 diabetes -- The approach to dietary prescription -- Failure of therapy -- Fat or carbohydrate.

Meal replacement therapy -- Very low calorie diets (VLCD) -- Conclusions -- References -- 7 Behavioural Modification in the Treatment of Obesity -- Introduction -- Genetics -- The 'toxic environment' -- Components of obesity treatment -- Features of behavioural lifestyle change -- Behavioural modification strategies in obesity treatment -- Efficacy of combination treatments -- Conclusions and future work -- References -- 8 Physical Activity, Obesity and Type 2 Diabetes -- Introduction -- Physical activity and exercise, what is the difference? -- Current physical activity behaviour and guidelines -- The importance of physical activity to health -- Energy balance -- Energy expenditure -- Exercise tolerance and cardiorespiratory fitness in overweight and obese adults and children -- Guidelines for exercise and activity prescription (including practical issues of clinical management for diabetics and the obese) -- Research evidence on the role of physical activity in the prevention and treatment of obesity and type 2 diabetes -- Physical activity and the behavioural treatment of obesity -- Linking research and practice -- Case study -- Summary -- References -- 9 Diabetes, Obesity and Cardiovascular Disease - Therapeutic Implications -- Introduction -- Obesity and mortality -- Obesity and cardiovascular disease -- Obesity and hypertension -- Obesity and dyslipidaemia -- Obesity, type 2 diabetes and insulin resistance -- Obesity and type 2 diabetes -- Insulin resistance and cardiovascular disease -- Type 2 diabetes and dyslipidaemia -- Type 2 diabetes and hypertension -- Type 2 diabetes and CHD -- Benefits of weight loss -- Exercise -- Pharmacotherapy -- Management of hypertension -- Management of dyslipidaemia -- Antiplatelet therapy -- Conclusion -- References -- 10 Drug Therapy for the Obese Diabetic Patient -- Introduction -- Drugs for hyperglycaemia.

The role of anti-obesity drugs in diabetic management -- Antihypertensive treatment -- Lipid-lowering treatment -- Use of other drugs that may cause weight gain -- References -- 11 The Role of Bariatric Surgery in the Management of Type 2 Diabetes -- Introduction -- Obesity and type 2 diabetes: -- Surgical techniques -- Resolution of diabetes after bariatric surgery -- How does surgery 'cure' diabetes? -- Conclusions -- References -- 12 Childhood Obesity and Type 2 Diabetes -- Introduction -- Childhood is a time of change -- The problem of size -- The size of the problem -- What causes obesity in childhood? -- Does obesity in childhood matter? -- Persistence in to adult life -- Management of childhood obesity -- Management of Complications -- Conclusions -- References -- 13 Obesity and Polycystic Ovary Syndrome -- Definition of the syndrome -- Pathogenetic mechanisms underlying the relationship between obesity and PCOS (Table 13.1) -- Clinical features of obese PCOS women -- Treatment of obese women with PCOS (Table 13.2) -- Conclusions -- References -- 14 Management of Diabesity in Primary Care: a Multidisciplinary Approach -- Prevalence of obesity in primary care -- Current approach to diabetes care in primary care -- Early treatment with hypoglycaemic agents -- Integrating obesity management with diabetes -- A multidisciplinary approach -- Dietary treatment of diabetes -- Clinical assessment -- Treatment groups -- Physical activity -- Behavioural change -- Use of medication to aid weight loss in primary care -- Summary -- References -- Index.