Contents -- Foreword (by John Wong) -- Foreword (by Kurt Hostettmann) -- Preface -- 1. Plants in Drug Discovery-Creating a New Vision -- INTRODUCTION -- NATURAL PRODUCTS IN DRUG DISCOVERY - THE FUTURE -- ACCESS TO THE BIOME -- ACQUISITION AND ANALYSIS OF TRADITIONAL KNOWLEDGE AND ON-GOING RESEARCH -- BIOTECHNOLOGY DEVELOPMENT -- SAFETY AND EFFICACY OF PLANT MEDICINAL AGENTS -- DEREPLICATION STUDJES -- NATURAL PRODUCT STRUCTURE DIVERSIFICATION -- CREATING A NEW VISION -- CHALLENGES FOR THE FUTURE -- CONCLUSION -- REFERENCES -- 2. The Bio-Extraction Industry in Jamaica: Potential and Challenges -- INTRODUCTION -- REFERENCES -- 3. Structural Studies of Drug Metabolising Enzymes and the Relevance to Natural Product Development -- INTRODUCTION -- THE IMPORTANCE OF DRUG METABOLISM IN DRUG DEVELOPMENT -- CYTOCHROME P450 (CYP) ENZYMES -- ARYLAMINE N-ACETYLTRANSFERASE (NAT) -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- 4. Bioinformatics-Species Diversity Databases: Tools for Facilitating Natural Product Research -- INTRODUCTION -- WHAT IS BIOINFORMATICS? -- WHAT ARE THE SUB-DISCIPLINES? -- DATA-CENTERED VIEW -- TECHNOLOGY-CENTERED VIEW -- WHAT UNIFYING FRAMEWORKS CAN BE FOUND FOR BIOLOGICAL DATASETS? -- CONCLUSION -- REFERENCES -- 5. From Genomes to Drugs with Bioinformatics -- INTRODUCTION -- SEQUENCE ANALYSIS -- SEQUENCE COMPARISON -- FINDING PARTICULAR SEQUENCE PATTERNS -- PROTEIN STRUCTURE PREDICTION -- PROTEIN-LIGAND DOCKING IN DRUG DESIGN -- MINING GENES FROM EXPRESSED SEQUENCE TAQ (EST) -- GENOME SEQUENCING -- TRENDS AND CHALLENGES -- REFERENCES -- 6. Yeast-Based Technologies for High Throughput Screening of Natural Anti-Viral Agents -- INTRODUCTION -- MATERIALS AND METHODS -- ACKNOWLEDGMENT -- REFERENCES.

7. Use of High-Density Oligonucleotide Microarrays for Gene Expression Profiling in Natural Product Research -- INTRODUCTION -- HIGH-DENSITY OLIGONUCLEOTIDE MICROARRAYS -- CHOICE OF SAMPLES -- TARGET PREPARATION HYBRIDISATION AND SCANNING -- DATA ANALYSIS AND DATA MINING -- POST-ANALYSIS CHALLENGES -- CONCLUSION -- REFERENCES -- 8. Limitations of Natural Pesticides: A Challenge to Scientists -- INTRODUCTION -- CONCLUSION -- REFERENCES -- 9. Bioactivity of Hexane Extract of Blighia Sapida Konig on the Cattle Tick Boophilus microplus and the Sweet Potato Weevil Cylas formicarius elegantulus -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- 10. Antibacterial Screening of Tragia involucrata L.(Euphorbiaceae) - A Tribal Used Medicinal Plant -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- 11. Effect of Crude Papaya Latex on Rats' Pregnancy -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- 12. 1-Cyano-2-Hydroxy-3-Butene: A Plant Nitrile that Induces Apoptosis in Pancreatic Acinar Cells and Reduces the Severity of Acute Pancreatitis -- INTRODUCTION -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- 13. The Liver Protective Effect of Sesamin -- INTRODUCTION -- CONCLUSION -- REFERENCES -- 14. Endothelium-Dependent Vascular Relaxation Induced by Extracts of Some Chinese Medicinal Herbs Traditionally Used to Remove Circulatory Stagnation: An Update -- INTRODUCTION -- EUCOMMIA ULMOIDES -- ELEUTHEROCOCCUS SENTICOSUS -- PANAX NOTOGINSENG -- RED WINE AND TEA -- CONCLUSION -- REFERENCES -- 15. Effect of Chronic Administration of Aqueous Azadirachta indica (Neem) Leaf Extract on the Cardiovascular System in the Rat -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES.

16. The Anti-Hypertensive Effect of Sesamin -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- REFERENCES -- 17. Effects of Salvia miltiorrhiza After Acute Myocardial Infarction in Rats -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- 18. The Antioxidant and Free Radical Scavenging Effects of Sesamin -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- 19. Anticancer and Immunomodulatory Potential of DRF-3188 an Analogue of Andrographolide -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- ACKNOWLEDGEMENT -- REFERENCES -- 20. Immunomodulating Property of Astragalus Membranaceus and Curcuma Aromatica -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- 21. Induction of Breast Tumours in Rats for Assaying Natural Products for Anti-Tumour Properties -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- 22. Cancer Diagnosis Using the Novel Photosensitizer Hypericin -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- 23. Chemopreventive Efficacy of Apigenin against N-Nitrosodiethylamine-Induced and Phenobarbital- Promoted Experimental Hepatoma -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES -- 24. The Effects of Saponin from Sea Cucumber (Holothuria atra Jaeger) on CEM-SS T-Lymphoblastic Cells -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- 25. Lentinan-A Medically Valuable Glucan -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES -- 26. Turmeric and Colon Cancer -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- REFERENCES.

27. Immunotherapy of Bladder Cancer Using Microbes -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- 28. Modulation of Hypericin-Based Phototoxicity in Nasopharyngeal Cancer -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- 29. Research and Development of Natural Products in Developing Countries: Need for Venture Capital -- INTRODUCTION -- MARKET GROWTH AND POTENTIAL -- CONCLUDING REMARKS -- REFERENCES -- 30. Protection of Ideas Inventions Trade Marks Copyrights and Products under the Intellectual Property Law -- INTRODUCTION -- PATENTS -- TRADE MARKS -- INDUSTRIAL DESIGNS -- COPYRIGHT ISSUES -- LAW OF CONFIDENCE AND TRADE SECRETS -- ENFORCEMENT ACTIONS -- CONCLUSION -- Index of Contributors.